Venkatesan R, et al. BMJ Case Rep 2017. doi:10.1136/bcr-2017-220628 Description A 65-year-old man presented with fever and painful swelling at the back for last 2 weeks. His prior history was significant for long-standing type 2 diabetes of 20 years duration and systemic hypertension. Clinical examination showed red, swollen, painful carbuncle with gangrenous patch at the centre and multiple pu...

Advent of pharmacology, combinatorial chemistry and High Through Put Screening offered large number of synthetic drugs as a therapeutic substances. These molecules are potent to elucidate their pharmacological activity. However, pharmacokinetic properties of such molecules are rate limiting factors for its safety as well as efficacy. Most of the synthetic drug available so far in market are eit...

More than 30% of patients with chronic paraproctitis have complex forms. They are most often complicated by external sphincter insufficiency due to deformation the anal canal and scarring sphincters. The main principle substantiation surgical treatment extrasphincteric pararectal fistulas is individual choice method in each particular patient. It based on a comprehensive assessment such factors...

The combustion of biomass and waste paper sludge in a fluidized bed is ecologically profitable. However, large amount by-product with high hydraulic reactivity produced considered as wastes. Most the time fly ash (WPFA) goes to landfills, therefore new utilization methods are necessary. In some countries, content metallic metalloids trace elements (MMTE) WPFA, more specifically Barium (Ba) Lead...

2/2001 Tiina Ojala Biological Screening of Plant Coumarins 3/2001 Helena Vihinen Expression, Purification and Characterization of Fungal and Viral Recombinant Proteins 4/2001 Viktor Kuvshinov Development of Transgenic Crops Protected from Insect Damage and Transgene Escape 5/2000 Harun Ar Rashid Centrifugal Granulating Process for Preparing Drug-Layered Pellets Based on Microcrystalline Cellulo...

Borate concentrated wastes generated from liquid waste evaporator of 12 pressurized water reactors (PWRs) have been processed to be dry using concentrated waste drying system (CWDS) in Korea. Borate wastes had been stabilized or solidified using paraffin as a binder since 1995, but the solidification process is stopped and concentrated wastes are just stored in drums and on standby at present b...

OBJECTIVE Successful prosthetic rehabilitation is crucial for quality of life in cases of large maxillary defects when surgical reconstruction is not advisable because of general health or patient refusal. For this purpose, the extended indications for Zygomaticus fixtures in different defect types were evaluated. PATIENTS AND METHODS Twelve patients received 28 zygoma implants and 23 dental ...

Background: A topical antimicrobial that can decrease the bacterial bioburden of chronic wounds without impairing the wound's ability to heal is a therapeutic imperative. A stabilized form of hypochlorous acid (NVC-101) has been demonstrated in vitro and in standard toxicity testing to possess properties that could fulfill these criteria. Materials and Methods: Using a standard rodent model of ...

Glimepiride (GMP) is poorly water soluble drug, so solubility is the main constraint for its oral bioavailability. The aim of this study was to investigate the potential of cubosomes as lipid nanocarrier to improve the solubility and sustained action of Glimepiride. Glimepiride is one of the third generation sulfonylureas used for treatment of type 2 diabetes. The rationale of this study was to...

The use of antiseptics in wound care is often controversial and there is definitely a need for a non toxic, highly disinfective agent. This study assessed the efficacy of a neutral pH superoxidised aqueous solution (NpHSS) for infection control, odour reduction and surrounding skin and tissue damage on infected diabetic foot ulcerations. From November 2003 to March 2004, 45 patients with type 2...