Granulomatous inflammation is an evolutionarily conserved immunologic reaction with macrophage-predominant patterns, and granuloma a more specific term referring to tightly associated clusters of macrophages epithelioid morphology.1Wang A. Singh K. Ibrahim W. King I. Damsky The promise JAK inhibitors for treatment sarcoidosis other inflammatory disorders macrophage activation: review the litera...

Sarcoidosis is a multisystem granulomatous disease, with an inadequately defined etiology affecting several organ systems. Cutaneous lesions provide important visible clues and an easily accessible source of tissue for histologic examination to reach early diagnosis and management. Along with a brief literature review, we report two cases presenting with rare forms of psoriasiform and annular s...

Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous skin disease of unclear pathogenesis which belongs to the group of disorders in the skin and elastic fibers with similar clinical features of granuloma annulare (GA). This case report is intended to describe a rare hybrid pattern in histopathology demonstrating coexistence of AEGCG and GA. An endocrine disease, such as dia...

Granulomas are focal infiltrates consisting mainly of macrophages or macrophage-derived cells (epithelioid, giant cells), chiefly in the case impossibility slow degradation specific antigens. The variability manifestations complicates clinical and pathological diagnosis granulomatous skin diseases due to individual patient reactivity specifics often unidentified triggering factors. mini-review ...