Heman airway preparations at resting tone were relaxed with either the leukotriene synthesis inhibitor BAY x1005 (3 muM), chlorpheniramine (1 muM) or the thromboxane receptor antagonist BAY u3405 (0.1 muM). The response to anti-IgE (1:1000) was 58 +/- 8% of acetylcholine pre-contraction (2.19 +/- 0.28 g). Indomethacin (3 muM) enhanced the anti-IgE-induced contraction by 28%. The anti-IgE maxima...

Persistent pulmonary hypertension of the newborn (PPHN) is partly due to impaired nitric oxide (NO)-cGMP signaling. BAY 41-2272 is a novel direct activator of soluble guanylate cyclase, but whether this drug may be an effective therapy for PPHN is unknown. We hypothesized that BAY 41-2272 would cause pulmonary vasodilation in a model of severe PPHN. To test this hypothesis, we compared the hemo...

The Chesapeake Bay benthic index of biotic integrity (B-IBI) was developed to assess benthic community health and environmental quality in Chesapeake Bay. The B-IBI provides Chesapeake Bay monitoring programs with a uniform tool with which to characterize bay-wide benthic community condition and assess the health of the Bay. A probability-based design permits unbiased annual estimates of areal ...

in this study variations of field data such as temperature, salinity and density in and across the transects of chahbahar bay were analyzed using ctd data acquired between winter 2006 and spring 2007 (winter monsoon).the results showed that thermocline layer intensify in mouth of bay between 2m and 6m with 7.81 ?c decrease before the gonou hurricane occured (mid-may 2007). below thermocline lay...

Although San Francisco Bay has a "Golden Gate", it may be argued that it is the "Silver Estuary". For at one time the Bay was reported to have the highest levels of silver in its sediments and biota, along with the only accurately measured values of silver in solution, of any estuarine system. Since then others have argued that silver contamination is higher elsewhere (e.g., New York Bight, Flo...

Choctawhatchee Bay is located in the western Florida panhandle. The system was originally oligohaline with input primarily from Choctawhatchee River which terminates at the east end of the bay. The Choctawhatchee Bay and River watershed has a drainage area of 5349 square miles in Florida and Alabama (NWFWMD, 1996). Historically, marine waters entered the bay via only periodic breakthroughs to t...

BAILLIE, P., TURNER, E. & QUILTY, P.G., 1985 (31:vii): Late Pleistocene marine sediments and fossils from Mussel Roe Bay, northeastern Tasmania. Pap. Proc.R.Soc. Tasm. 119:83-87. ISSN 0080-4703. Geological Survey of Tasmania, Tasmanian Museum and Art Gallery and Antarctic Division, Hobart, Tasmania, Australia. Foraminiferaand mollusc-bearing estuarine sediments were encountered in one of a seri...

BACKGROUND AND AIMS Nitric oxide-independent soluble guanylyl cyclase (sGC) activators reactivate the haem-oxidized enzyme in vascular diseases. This study was undertaken to investigate the anti-platelet mechanisms of the haem-independent sGC activator BAY 60-2770 in human washed platelets. The hypothesis that sGC oxidation potentiates the anti-platelet activities of BAY 60-2770 has been tested...

BACKGROUND Although evidence now suggests cGMP is a negative regulator of cardiac hypertrophy, the direct consequences of the soluble guanylyl cyclase (sGC) activator BAY 58-2667 on cardiac remodeling, independent of changes in hemodynamic load, has not been investigated. In the present study, we tested the hypothesis that the NO(•)-independent sGC activator BAY 58-2667 inhibits cardiomyocyte h...