When starting a new collaborative endeavor, it pays to establish upfront how strongly your partner commits to the common goal and what compensation can be expected in case the collaboration is violated. Diverse examples in biological and social contexts have demonstrated the pervasiveness of making prior agreements on posterior compensations, suggesting that this behavior could have been shaped...

The 70-gene signature (MammaPrint) is a prognostic tool used to guide adjuvant treatment decisions. The aim of this study was to assess its value to predict chemosensitivity in the neoadjuvant setting. We obtained the 70-gene profile of stage II–III patients prior to neoadjuvant chemotherapy and classified the prognosissignatures. Pathological complete remission (pCR) was used to measure chemos...

Consider the following heuristic for planar Euclidean instances of the traveling salesman problem (TSP): select a subset of the edges which induces a planar graph, and solve either the TSP or its graphical relaxation on that graph. In this paper, we give several motivations for considering this heuristic, along with extensive computational results. It turns out that the Delaunay and greedy tria...

In order to ensure the quality of their software development, companies incorporate best practices from recognized repositories or from their own experiences. These best practices are often described in software quality manuals which does not guarantee their implementation. In this paper, we propose a framework for the implementation of best practices concerning the design of the software archi...

in MFI values, however it was not statisticlly significant. The mean percentage of CD19/TNF-α cells was significantly higher, while the percentage of CD19/IL-2, CD19/IL-4 and CD19/ IFN-γ was lower in ZAP-70 positive than ZAP-70 negative patients. There was no significant difference between ZAP-70 positive and ZAP-70 negative group as far as MFI was concerned. Conclusions. Our findings demonstra...