*Professor of Medicine, T.N. Medical College (Retd.), Hon. Physician, Bhatia Hospital, Mumbai H (460 B.C. 370 B.C.) was a Greek physician universally known as father of medicine. Very little is known about what he actually thought and did. Scanty information about Hippocrates is found in the writings of Aristotle and Plato. Ancient biographer of Hippocrates Soranus mentions that he was born on ...

An important goal is to identify the direct activation domain (AD)-interacting components of the transcriptional machinery within the context of native complexes. Toward this end, we first demonstrate that the multisubunit TFIID, SAGA, mediator, and Swi/Snf coactivator complexes from transcriptionally competent whole-cell yeast extracts were all capable of specifically interacting with the prot...

RATIONALE Bunyaviruses have become a major threat to both humans and livestock in Europe and the Americas. The nucleocapsid (N) protein of these viruses is key to the replication cycle and knowledge of the N oligomerisation state is central to understanding the viral lifecycle and for development of therapeutic strategies. METHODS Bunyamwera virus and Schmallenberg virus N proteins (BUNV-N an...

Rhp14 of Schizosaccharomyces pombe is homologous to human XPA and Saccharomyces cerevisiae Rad14, which act in nucleotide excision repair of DNA damages induced by ultraviolet light and chemical agents. Cells with disrupted rhp14 were highly sensitive to ultraviolet light, and epistasis analysis with swi10 (nucleotide excision repair) and rad2 (Uve1-dependent ultraviolet light damage repair pat...

Leptospirosis is a worldwide zoonosis caused by pathogenic Leptospira. The whole-genome sequence of L. interrogans serovar Copenhageni together with bioinformatics tools represent a great opportunity to search for novel antigen candidates that could be used as subunit vaccine against leptospirosis. We focused on six genes encoding for conserved hypothetical proteins predicted to be exported to ...

Intracellular delivery of functional macromolecules using peptide transduction domains (PTDs) is an exciting technology with both experimental and therapeutic applications. Recent data indicate that PTD-mediated transduction occurs via fluid-phase macropinocytosis involving an intracellular pH drop to approximately 5. Nitrilotriacetic acid (NTA)-coordinated metals avidly bind hexahistidine-tagg...

the political, social, and religious conflicts between the church and the protestants during the renaissance and afterward gave a unique dimension to the works of a large number of european artists such as shakespeare. a few decades later, art critics defined this style under the rubric of baroque. the writers of this article conduct an explanatory analysis of shakespeare’s hamlet in the light ...

II.?The origin of Fever?the king of diseases.?Shiva, the lord of the three worlds, being angry with Raja Duksh, his father-in-law, because he had not invited him to a sacrifice, and because his wife had committed sutti, sent a demon whom lie had created from his third eye to destroy the Raja and his sacrifice. This personage accomplished the work so satisfactorily that his master changed his na...

4 studies investigated the broad claim that preschoolers understand biological inheritance. In Study 1, 4-7-year-old children were told a story in which a boy was born to one man and adopted by another. The biological father was described as having one set of features (e.g., green eyes) and the adoptive father as having another (e.g., brown eyes). Subjects were asked which man the boy would res...

Carlos Castillo-Chavez's tenure at Cornell University with Simon Levine, also marks the beginning of my life as his daughter. I was nine months old when I arrived to Ithaca, and my recollections of my father in elementary school and middle school were of him furiously writing equations at his desk, or outside on the chalk board in our shed, or on napkins, notepads or anything he could get his h...