609 samples of drinking water collected from scattered sources from the eight districts of Kandy, Matale, Kalutara, Anuradhapura, Polonnaruwa, Colombo,. Puttalam and Gampaha were analysed for iodide content using the Orion electrode method. The median iodide content of all districts except Gampaha were above 10 u g / 1 , with Anuradhapura showing the highest content. Districts with low prevalen...

Ahigher frequency of skewed X chromosome inactivation (XCI) is found in patients with autoimmune thyroid disease (AITD) than in controls. Although goitre is often present in AITD, a recent study failed to show an association between XCI and clinically overt nontoxic goitre. However, the etiology of overt goitre is complex, and the mechanisms influencing thyroid volume may involve fewer factors ...

BACKGROUND We have sought to establish the prevalence of goitre within a Pendred syndrome (PS) cohort and to document the course of thyroid disease in this patient group. As part of a genetic study of PS we have assessed 57 subjects by perchlorate discharge test and in 52 (M 21, F 31, age range 9-54 years) a discharge of radioiodide of >10% was observed. RESULTS Goitre was present in 43 (83%)...

INTRODUCTION Hashimoto's thyroiditis (HT) is a common cause of goitre and hypothyroidism in children and adolescents. Spontaneous remission may occur in up to 50% patients, but the development of hypothyroidism is possible. OBJECTIVE We investigated the clinical manifestations, course and long-term outcome of HT. METHOD We reviewed charts of 43 children (36 females) with HT, mean age at pre...

Sporadic non-toxic goitre (SNG) is defined as thyroid enlargement in a euthyroid patient living in an area without endemic goitre. Because thyroid hormone function is within the reference range, the main problems are the signs of thyroid enlargement, thus reducing the size of the goitre is undoubtedly the primary goal of therapy. Although SNG is a common disease, there is no single optimal mana...

BACKGROUND Smoking has been associated with Graves' disease, but it remains unclear if the association is present in other thyroid disorders. OUTCOME VARIABLES Graves' disease, Graves' ophthalmopathy, toxic nodular goitre, non-toxic goitre, post-partum thyroid disease, Hashimoto's thyroiditis, or hypothyroidism. MATERIAL AND METHODS A search of MEDLINE identified 25 studies on the associati...

To cite: Katoh H, Enomoto T, Watanabe M. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/ bcr-2015-210634 DESCRIPTION A 60-year-old man presented with an 18-month history of deteriorating facial oedema and intermittent oedema of upper limbs. He had symptoms of headache, flush, dysphagia and coughs. He also noted hoarseness or dysphonia after standing for long periods....

BACKGROUND in recent years, an increasing interest in the application of selective embolization of thyroid arteries (SETA) in the treatment of thyroid diseases is observed. In the present report, we analyse the value, safety and possible indications for preresective SETA in cases of large toxic goitres. PATIENTS AND METHOD the study group comprised 10 patients with large toxic goitre (thyroid...

OBJECTIVE To describe the status of iodine deficiency disorders (IDDs) in the Sudan more than 25 years after the initiation of IDD control programmes and to explore the causes of endemic goitre in the country. METHODS Testing for IDDs was carried out in 6083 schoolchildren 6 to 12 years of age from the capital cities of nine states in different areas of the country using the three indicators ...