نتایج جستجو برای: glyoxylated polyacrylamide gpam and polyamide
تعداد نتایج: 16829279 فیلتر نتایج به سال:
Hairpin pyrrole-imidazole (Py-Im) polyamides are a class of cell-permeable DNA-binding small molecules that can disrupt transcription factor-DNA binding and regulate endogenous gene expression. The covalent linkage of antiparallel Py-Im ring pairs with an gamma-amino acid turn unit affords the classical hairpin Py-Im polyamide structure. Closing the hairpin with a second turn unit yields a cycl...
Pyrrole-imidazole (Py-Im) polyamides can bind to the predetermined base pairs in the minor groove of double-helical DNA with high affinity. These synthetic small molecules can interfere with transcription factor-DNA interaction and inhibit or activate the transcription of corresponding genes. In the present study, we designed and synthesized a Py-Im polyamide to target 545 to 539 base pairs of ...
We report a preclinical study of a pyrrole-imidazole (PI) polyamide that targets the human transforming growth factor (hTGF)-β1 gene as a novel transcriptional gene silencer in a common marmoset primate model. We designed and then synthesized PI polyamides to target the hTGF-β1 promoter. We examined effects of seven PI polyamides (GB1101-1107) on the expression of hTGF-β1 mRNA stimulated with p...
A pivotal step forward in chemical approaches to controlling gene expression is the development of sequence-speci®c DNA-binding molecules that can enter live cells and traf®c to nuclei unaided. DNAbinding polyamides are a class of programmable, sequence-speci®c small molecules that have been shown to in ̄uence a wide variety of protein±DNA interactions. We have synthesized over 100 polyamidēuoro...
Regulation of endogenous genes by DNA-binding polyamides requires effective nuclear localization. Previous work employing confocal microscopy to study uptake of fluorophore-labeled polyamides has demonstrated the difficulty of predicting a priori the nuclear uptake of a given polyamide. The data suggest that dye identity influences uptake sufficiently such that a dye-conjugate cannot be used as...
Artemisinin extracted from Artemisia annua L. is the best medicine with the highest efficiency, the most effective and the lowest toxicity in treating ague nowadays. At present, most studies focus on artemisinin and its derivatives, while the study and report about the other active components are rare. This paper purposed to further discover new indication of Artemisia annua L. connecting with ...
An Experimental Study on the Tensile Behaviors of Ultrasonic Welded T-joints for Polyamide Composite
In this paper, an experimental investigation on ultrasonic welding of polyamide composites reinforced with glass fiber has been carried out. The effect of ultrasonic welding parameters, such as welding time, air pressure, hold time and the amount of glass fiber in the composite on tensile strength of weld joints were determined using response surface methodology. This methodology was applied fo...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید