© Japi • January 2014 • Vol. 62  9 I n o r m a l h u m a n e r y t h r o c y t e s , HbA comprises > 90% of the total haemoglobin. Besides HbA, human erythrocytes contain other haemoglobin components that are of considerable interest. Some of these, such as HbA2 and foetal haemoglobin (HbF), like s i c k l e c e l l h a e m o g l o b i n , a r e t h e products of al ternate globin chain genes ...

CONTEXT Most antidiabetic agents target only 1 of several underlying causes of diabetes. The complementary actions of the antidiabetic agents metformin hydrochloride and rosiglitazone maleate may maintain optimal glycemic control in patients with type 2 diabetes; therefore, their combined use may be indicated for patients whose diabetes is poorly controlled by metformin alone. OBJECTIVE To ev...

CONTEXT In patients with diabetes mellitus, depression is a prevalent and recurrent problem that adversely affects the medical prognosis. OBJECTIVE To determine whether maintenance therapy with sertraline hydrochloride prevents recurrence of major depression in patients with diabetes. DESIGN A randomized, double-blind, placebo-controlled, maintenance treatment trial. Patients who recovered ...

This study evaluates an integrated model of care for children with diabetes that was developed at a health maintenance organization (HMO). This model program of 56 subjects included a nurse case manager, a multidisciplinary clinic team, and educational and counseling interventions to empower families to improve self-management of the children's diabetes. The purpose of the program was to improv...

OBJECTIVE To determine the frequency and factors associated with hypomagnesaemia in hypokalemic type-2 diabetic patients presenting at Civil Hospital, Karachi. STUDY DESIGN A cross-sectional study. PLACE AND DURATION OF STUDY Department of Medicine and Diabetic Clinic of Civil Hospital and Dow Medical College, Karachi, from November 2010 to May 2011. METHODOLOGY A total of 358 adult type-...

OBJECTIVE Difficulties collaborating with providers and important others may adversely influence self-management in patients with diabetes. We predicted that dismissing attachment style, characterized by high interpersonal self-reliance and low trust of others, would be associated with poorer self-management in patients with diabetes. METHODS A population-based mail survey was sent to all pat...

BACKGROUND The excretion of small amounts of urinary protein, known as microalbuminuria, among patients with essential hypertension is associated with increased mortality from cardiovascular disease and, possibly, future renal decline. Correlates of microalbuminuria among primary care patients with essential hypertension, however, have not been well described. METHODS One hundred forty patien...