نتایج جستجو برای: glycogen synthase kinase
تعداد نتایج: 311187 فیلتر نتایج به سال:
Sphingosine kinase-1 (Sphk1) and its product, sphingosine-1-phosphate (S1P) are important regulators of cardiac growth function. Numerous studies have reported that Sphk1/S1P signaling is essential for embryonic development promotes pathological hypertrophy in adulthood. However, no addressed the role Sphk1 postnatal cardiomyocyte (CM) so far. The present study aimed to assess molecular mechani...
Phosphorylation of rabbit muscle glycogen synthase by cyclic AMP-dependent protein kinase has been shown to enhance subsequent phosphorylation by casein kinase I (Flotow, H., and Roach, P. J. (1989) J. Biol. Chem. 264, 9126-9128). In the present study, synthetic peptides based on the sequences of the four phosphorylated regions in muscle glycogen synthase were used to probe the role of substrat...
Defects in liver and muscle glycogen synthesis are major factors contributing to postprandrial hyperglycemia in patients with type 2 diabetes. Therefore, activation of glycogen synthase through inhibition of glycogen synthase kinase (GSK)-3 represents a potential new therapeutic target. To examine this possibility, we performed oral glucose tolerance tests (OGTTs) and euglycemic-insulinemic cla...
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