yglutamyl amino acids and for glutathione. Transport of y-glutamylmethionine is associated with markedly increased renal 5-oxoproline formation, indicating that transported dipeptide serves as a substrate of intracellular yglutamylcyclotransferase (R. J. Bridges & A. Meister, unpublished work). Previous investigations showed that renal 5-oxoproline levels are significantly elevated after admini...

Glutathione is the major cellular thiol present in mammalian cells and is critical for maintenance of redox homeostasis. However, current assay systems for glutathione lack application to intact animal tissues. To map the levels of glutathione in intact brain with cellular resolution (acute tissue slices and live animals), we have used two-photon imaging of monochlorobimane fluorescence, a sele...

background: corn silk (cs) is widely used in iranian traditional medicine and feijoa sellowiana(fs) is a native plant widespread in the southern parts of iran. the aim of the present study was to assess renal protective activities of cs and fs against dosage induced injury by ecstasy (mdma) using insitu rat renal perfusion (irrp) system.methods: hydro-alcoholic extract of cs and fs (10, 20, 40 ...

two-dimensional electrophoresis (2-d electrophoresis) is a powerful and extensively used method for analysis of complex protein mixtures extracted from cells, tissue, or other biological samples such as helminth parasites including, f. hepatica. each spot on the resulting two-dimensional collection corresponds to a single protein species in the sample. this study was carried out to detect of gs...

orchard workers in north china are highly exposed to orchard pollens, especially peach and other rosaceae family pollens during pollination season. the aim of this study was to investigate whether occupational allergy to peach tree pollen as a member of rosaceae family is ige-mediated and to evaluate the cross-reactivity among rosaceae family pollens. allergen skin test and conjunctival challen...

background: the aim of the present study was to evaluate the radioprotective effect of grewia asiatica fruit pulp extract (gae) on swiss albino mice exposed to gamma radiation. in the present study radioprotective efficacy of grewia asiatica (rich in anthocyanin, carotenes, vitamin c, etc.) was studied against radiation induced biochemical alterations in mice cerebrum. materials and methods: fo...

During inflammatory processes, immunocompetent cells are exposed to substantial amounts of free radicals and toxic compounds. Glutathione is a cysteine-containing tripeptide that an important ubiquitous antioxidant molecule produced in human organs. The intracellular content GSH regulates the detoxifying capacity cells, as well immune response. particularly liver, where it serves major non-prot...

Glutathione is an important antioxidant and has many important functions in plant development, growth and defense. Glutathione synthesis and degradation is highly compartment-specific and relies on the subcellular availability of its precursors, cysteine, glutamate, glycine and γ-glutamylcysteine especially in plastids and the cytosol which are considered as the main centers for glutathione syn...