نتایج جستجو برای: glutamatergic transmission

تعداد نتایج: 251772  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2000
J Feng Z Yan A Ferreira K Tomizawa J A Liauw M Zhuo P B Allen C C Ouimet P Greengard

Spinophilin, a protein that interacts with actin and protein phosphatase-1, is highly enriched in dendritic spines. Here, through the use of spinophilin knockout mice, we provide evidence that spinophilin modulates both glutamatergic synaptic transmission and dendritic morphology. The ability of protein phosphatase-1 to regulate the activity of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropioni...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2005
Angèle T Parent Natalie Y Barnes Yoshihito Taniguchi Gopal Thinakaran Sangram S Sisodia

Presenilin (PS) plays an essential role in intramembranous gamma-secretase processing of amyloid precursor protein (APP) and several membrane-bound proteins. Here we report that selective accumulation of a membrane-tethered deleted in colorectal cancer (DCC) derivative (DCC-alpha) correlates with extensive neurite outgrowth in transfected neuroblastoma cells and axodendritic connectivity associ...

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