H omozygous sickle cell disease (SCD) is an auto-somal recessive genetic disease that results from the substitution of valine for glutamic acid at position 6 of the β-globin gene, leading to production of a defective form of hemoglobin, hemoglo-bin S (HbS). The prevalence of SCD is about 1-2% among African descendants in Europe and the United States and 4% or higher in West Africa. SCD shows br...

HIGHLIGHTS The combined use of fasting plasma glucose and hemoglobin A1c test is associated with significantly higher diagnostic rates of prediabetes across age, race/ethnicity, and BMI than using only one test.Combined use of fasting plasma glucose, hemoglobin A1c, and oral glucose tolerance test do not improve the overall and gender-specific prediabetes prevalence beyond what is observed usin...

This study aims to investigate the effects of controlled low central venous pressure combined with dexmedetomidine on blood loss, renal function and cognitive in patients undergoing laparoscopic hepatectomy. From January 2021 October 2022, 90 treated hepatectomy Huai’an First People’s Hospital were selected as subject objects equally divided into group control a random method. The surgical dura...

patients and methods in this cross-sectional study, the hemoglobin levels of 52 patients with end-stage renal disease were measured before and after hemodialysis. the required erythropoietin doses and the differences in cost were calculated based on the hemoglobin levels before and after hemodialysis. a model to predict the adjusted erythropoietin dosages based on post-hemodialysis hemoglobin l...

The aim of the study was to evaluate combination functional status tools (American Society Anesthesiologists Physical Status Classification System (ASA PS)) status, Metabolic Equivalent Task (METs), Revised Cardiac Risk Index for Pre-Operative (RCRI) largely used in preoperative risk assessment with humoral variables building powerful predictive models Major Adverse Cerebrovascular Events (MACC...

J. B. S. Haldane (13) was the first to study theoretically the equilibrium between hemoglobin and mixtures of 02 and CO which were of insufficient concentration to saturate the hemoglobin completely. His treatment was subsequently amplified and modified by A. V. Hill (15), Stadie and Martin (23), Barcroft (4), and Peters and Van Slyke (19). As a result of this work it has been generally accepte...

The biguanide, metformin, is considered first-line treatment for type 2 diabetes. Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor acts through the incretin pathway and has a glucose dependent mode of action. The complementary hypoglycemic properties of these drugs make fixed dose combination treatment an attractive prospect. Evidence from recent clinical trials suggests a beneficial eff...

BACKGROUND Hemoglobin concentration (Hb) and left ventricular ejection fraction (EF) are known predictors of contrast induced nephropathy (CIN). We hypothesized that combination of Hb concentration and left ventricular EF is superior to either variable alone in predicting contrast induced nephropathy in patients with acute coronary syndrome (ACS). MATERIAL AND METHODS Consecutive patients wit...