To express growth-related changes in physiologic or other functions in forms usable for kinetic modeling, we are interested in identifying regular relationships that take the form of simple mathematical expressions. Many anatomic and physiologic functions scale within or across species in accordance with the allometric relationship, y = axb. These include many organ weights, the glomerular filt...

A method is described for the semi-automated measurement of inulin concentrations in serum and urine in the presence of glucose. The concentration of glucose is measured simultaneously and is used to correct for almost all "inulin-like" interferences. The inulin standard curve is linear over a wide range (5-2500 mg/l). Between-run precision is < 6% and recovery from spiked sera is 98%. This met...

Na primeira leitura, o relato de Spanaus et al.(13) no Clinical Chemistry pode ser descartado como apenas mais uma comparação entre biomarcadores séricos para taxa de filtração glomerular (TFG). Entretanto, os resultados e as conclusões deverão estimular uma reavaliação da concepção errônea, amplamente disseminada, de que a creatinina sérica é um biomarcador insensível da TFG e uma afirmação do...

The glomerular filtration rate (GFR) is widely considered the best overall index of renal function. The Schwartz equations are designed for measuring the GFR in children between 1 and 16 years of age. In the present study, we investigated the percentiles of the GFR in a general population of Iranian children with no known renal disease via the 2009 Schwartz equations (updated and combined equat...

OBJECTIVE Pneumoperitoneum during laparoscopy results in transient oliguria and decreased glomerular filtration and renal blood flow. The presence of oliguria and elevated serum creatinine is suggestive of acute renal injury. Serum cystatin C has been described as a new marker for the detection of this type of injury. In this study, our aim was to compare the glomerular filtration rate estimate...

• Several glomerular filtration rate (GFR) prediction equations that take into account the serum creatinine concentration and certain patient variables (age, gender, body size and/or race) have been shown to generate sufficiently precise, unbiased and accurate estimates of GFR (eGFR) to be clinically useful for evaluating kidney function in a broad range of clinical settings. (Level III evidenc...

Introduction High urinary calcium excretion (UCaE) has been shown to lead to accelerated renal function decline in individuals with renal tubular diseases. It is not known whether this association also exists in the general population. Therefore, we investigated whether high UCaE is associated with risk of developing chronic kidney disease (CKD) in community-dwelling subjects. Methods Urine s...

BACKGROUND Variations in the timing of dialysis initiation may explain some geographical variations in renal replacement therapy (RRT) incidence, but this effect has never been quantified. METHODS Using data from the French Renal Epidemiology and Information Network registry, we quantified the association between RRT incidence in 2006-07 and median estimated glomerular filtration rate (eGFR) ...