نتایج جستجو برای: glioblastoma multiforme

تعداد نتایج: 26725  

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2006
Gelsomina De Stasio Deepika Rajesh Judith M Ford Matthew J Daniels Robert J Erhardt Bradley H Frazer Tolek Tyliszczak Mary K Gilles Robert L Conhaim Steven P Howard John F Fowler François Estève Minesh P Mehta

PURPOSE We present preclinical data showing the in vitro intranuclear uptake of motexafin gadolinium by glioblastoma multiforme cells, which could serve as a prelude to the future development of radiosensitizing techniques, such as gadolinium synchrotron stereotactic radiotherapy (GdSSR), a new putative treatment for glioblastoma multiforme. EXPERIMENTAL DESIGN In this approach, administratio...

Journal: :International journal of clinical and experimental pathology 2015
Ramir Arcega William H Yong Haodong Xu

We present a case of metastatic malignant melanoma in a patient initially diagnosed with glioblastoma multiforme, giant cell variant. A forty year old female presented to our institution for a re-resection of a recurrent right parietal lobe mass, presumed to be recurrent glioblastoma multiforme. PET scan during preoperative evaluation revealed a 3 cm left lower lobe lung mass. Metastatic gliobl...

2013
Birgit Flechl Marco Ronald Hassler Gerhard Kopetzky Peter Balcke Christine Kurz Christine Marosi Mari-Paule Thiet Deborah Blumenthal

We report the case of a woman with relapsed glioblastoma multiforme (GBM) who recently gave birth. She announced her pregnancy shortly after the sixth cycle of a dense regimen of temozolomide, prescribed for treating the first recurrence of glioblastoma. Three years ago, in April 2008, she had undergone gross total resection of a glioblastoma multiforme in the postcentral region of the right he...

2016
Ugan Singh Meena Sumit Sharma Sanjeev Chopra Shashi Kant Jain

Gliosarcoma is rare central nervous system tumour and a variant of glioblastoma multiforme with bimorphic histological pattern of glial and sarcomatous differentiation. It occurs in elderly between 5(th) and 6(th) decades of life and extremely rare in children. It is highly aggressive tumour and managed like glioblastoma multiforme. A 12-year-old female child presented with complaints of headac...

2017
Chao-Xiong Shen Jian-Feng Wu Wei Zhao Zhao-Wen Cai Ran-Ze Cai Chun-Mei Chen

RATIONALE Primary spinal glioblastoma multiforme (GBM) is a rare clinical entity with an aggressive course and an invariably dismal prognosis. Its clinical characteristics, radiologic and pathologic findings, and treatment protocols have been discussed in a few cases. PATIENT CONCERNS A 15-year-old female was admitted to the neurology department with a chief complaint of progressive numbness ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2000
E C Holland

G lioblastoma multiforme is the most aggressive of the gliomas, a collection of tumors arising from glia or their precursors within the central nervous system. Clinically, gliomas are divided into four grades; unfortunately, the most aggressive of these, grade 4 or glioblastoma multiforme (GBM), is also the most common in humans. Because most patients with GBMs die of their disease in less than...

2014
Dinisha Einstien Hemalatha Ganapathy

Glioblastoma multiforme is an aggressive astrocytic tumour with poor prognosis. Multifocal glioblastomas are uncommon lesions which can mimic secondaries,but treatment of these two disease entities is considerably different. Histopathology and immunohistochemistry are imperative for arriving at the correct diagnosis and planning the mangement. Here we present a case of multifocal glioblastoma, ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2012
Sung-Suk Suh Ji Young Yoo Gerard J Nuovo Young-Jun Jeon Seokho Kim Tae Jin Lee Taewan Kim Arianna Bakàcs Hansjuerg Alder Balveen Kaur Rami I Aqeilan Flavia Pichiorri Carlo M Croce

MicroRNAs (miRNAs) are increasingly implicated in regulating cancer initiation and progression. In this study, two miRNAs, miR-25 and -32, are identified as p53-repressed miRNAs by p53-dependent negative regulation of their transcriptional regulators, E2F1 and MYC. However, miR-25 and -32 result in p53 accumulation by directly targeting Mdm2 and TSC1, which are negative regulators of p53 and th...

2017
Chengrui Yan Xiangyi Kong Hua Yin Yu Wang Huayu He Hui Zhang Jun Gao Yongning Li Wenbin Ma

Spinal glioblastoma multiforme is not common among spinal cord tumors. According to our literature review, only 27 cases originating from the conus medullaris were reported. We herein reported a case of a 10-year-old child diagnosed with glioblastoma multiforme. The patient received adjuvant radiotherapy and standard temozolomide chemotherapy after total excision. Intracranial lesions were foun...

2013
Deric M. Park Jinkyu Jung Jimmy Masjkur Stylianos Makrogkikas Doreen Ebermann Sarama Saha Roberta Rogliano Nicoletta Paolillo Simone Pacioni Ron D. McKay Steve Poser Andreas Androutsellis-Theotokis

Tumors exhibit complex organization and contain a variety of cell populations. The realization that the regenerative properties of a tumor may be largely confined to a cell subpopulation (cancer stem cell) is driving a new era of anti-cancer research. Cancer stem cells from Glioblastoma Multiforme tumors express markers that are also expressed in non-cancerous neural stem cells, including nesti...

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