The venoms of predatory marine cone snails, Conus species, contain numerous peptides and proteins with remarkably diverse pharmacological properties. One group of peptides are the alpha-conotoxins, which consist of 13-19 amino acids constrained by two disulphide bonds. A biologically active fluorescein derivative of Conus geographus alpha-conotoxin GI (FGI) was used in novel solution-phase-bind...

CONTEXT Conventional dietary approaches for the treatment of obesity have generally yielded disappointing results. OBJECTIVE To examine the effects of a low-glycemic index (GI) diet compared with a standard reduced-fat diet in the management of pediatric obesity. DESIGN Retrospective cohort study of children attending an outpatient pediatric obesity program from September 1997 to December 1...

BACKGROUND Upper gastrointestinal (GI) symptoms such as nausea and vomiting are common adverse events associated with selective serotonin reuptake inhibitors (SSRIs), and may result in discontinuation of drug therapy in patients with depressive disorder. Rikkunshi-to (formulation TJ-43), a traditional herbal medicine, has been reported to improve upper GI symptoms and comorbid depressive sympto...

BACKGROUND There has been increasing interest in utilizing a diet low in fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) for the treatment of irritable bowel syndrome (IBS), a functional gastrointestinal disease. While studies have indicated that this diet can be effective at symptom reduction, it is a restrictive diet and patients may find it challenging to f...

BACKGROUND Our purpose was to report acute gastrointestinal (GI) and genitourinary (GU) toxicity rates for prostate cancer patients undergoing image-guided intensity modulated radiation therapy (IG-IMRT) with a daily endorectal water-filled balloon (ERBH2O), and assess associations with planning parameters and pretreatment clinical characteristics. METHODS The first 100 patients undergoing pr...

BACKGROUND To reduce unnecessary ambulatory gastroenterology (GI) visits and increase access to GI care, San Francisco Health Network gastroenterologists and primary care providers implemented guidelines in 2013 that discharged certain patients back to primary care after endoscopy with formal written recommendations. This study assesses the longer-term impact of this policy on GI clinic access,...

Uezono, Yasuhito, Muneshige Kaibara, Osamu Murasaki, and Kohtaro Taniyama. Involvement of G protein -subunits in diverse signaling induced by Gi/o-coupled receptors: study using the Xenopus oocyte expression system. Am J Physiol Cell Physiol 287: C885– C894, 2004. First published May 19, 2004; 10.1152/ajpcell.00125. 2004.—We studied the functions of -subunits of Gi/o protein using the Xenopus o...

Background: The coronavirus disease 2019 (COVID-19) pandemic has affected human life for more than a year. COVID-19 is well known its respiratory manifestations; however, other important symptoms help with diagnosis. Although clinical presentations in adults have been understood, data pediatric cases are still lacking. Objectives: We investigated gastrointestinal (GI) manifestations of cases. M...

A banda gástrica é considerada um tratamento menos eficiente que a derivação gástrica em Y de Roux, mas ainda é utilizada pela facilidade de realização e pelo baixo índice de mortalidade peroperatória. A longo prazo, as complicações têm sido muito altas, tornando a cirurgia quase proibitiva.1 Apresentamos um caso de megaesôfago grau IV póscirurgia de banda gástrica para tratamento de obesidade ...

Since December 2019, COVID-19 has caused huge global morbidity and mortality.[1][1] Although the disease is primarily a respiratory illness, gastrointestinal (GI) symptoms are increasingly recognised.[2][2] However, reported literature on prevalence of these conflicting, as their