Normal somatic growth requires that both the thyroid hormone axis and GH axis be intact. Thyroid hormone stimulates GH secretion, and many thyroid hormone actions on the insulin-like growth factor (IGF) system can be explained by this mechanism. We have previously described distinct changes in IGF binding protein (IGFBP) expression in experimental hypothyroidism in the rat; these changes could ...

The current study dealt with the interaction of garlic homogenate (GH) with propranolol (PRO) in rat, and to determine whether this effect is associated with biochemical and histological changes. Albino rats were treated with GH at three different doses of 125 mg/kg (GH-125), 250 mg/kg (GH-250) and 500 mg/kg (GH-500) orally for 30 days and PRO was incorporated in the interactive groups during t...

BACKGROUND Hypoparathyroidism in children is a heterogeneous group with diverse genetic etiologies. To aid clinicians in the investigation and management of children with hypoparathyroidism, we describe the phenotype of a 6-year-old child with hypoparathyroidism and short stature diagnosed with Kenny-Caffey syndrome (KCS) Type 2 and the subsequent response to growth hormone (GH) treatment. CA...

Diabetic retinopathy and acromegaly are diseases associated with excess action of GH and its effector IGF-I, and there is a need for improved therapies. We have designed an optimised 2'-O-(2-methoxyethyl)-modified phosphorothioate oligodeoxynucleotide, ATL 227446, and demonstrated its ability to suppress GH receptor mRNA in vitro. Subcutaneous injections of ATL 227446 reduced GH receptor mRNA l...

The fundamental challenge of developing a long-acting growth hormone (LAGH) is to create a more convenient growth hormone (GH) dosing profile while retaining the excellent safety, efficacy and tolerability of daily GH. With GH receptors on virtually all cells, replacement therapy should achieve the same tissue distribution and effects of daily (and endogenous) GH while maintaining levels of GH ...

CONTEXT AND OBJECTIVE A single missense mutation in the GH-1 gene converting codon 77 from arginine (R) to cysteine (C) yields a mutant GH-R77C peptide, which was described as natural GH antagonist. DESIGN, SETTING, AND PATIENTS Heterozygosity for GH-R77C/wt-GH was identified in a Syrian family. The index patient, a boy, was referred for assessment of his short stature (-2.5 SD score) and par...

We describe the use of four monoclonal antibodies (MAbs) to the rabbit liver growth hormone (GH) receptor and one raised against purified rat liver GH receptor to characterize liver receptor subtypes which differ in their hormone-binding regions. The anti-(rat liver GH receptor) MAb both inhibited and precipitated rat and rabbit GH receptors, but only one-half of 125I-oGH (ovine GH) binding to ...

GH-releasing factor (GRF) is the hypothalamic peptide that stimulates both synthesis and secretion of GH. The GRF signal is transduced to somatotroph cells through pituitary GRF receptors and generates episodic bursts of GH secretion into the bloodstream. Secretion of GH is highly sexually dimorphic, particularly in the rat [1]. In female rats, GH surges are of lower amplitude and occur more ir...

growth hormone and insulin-like growth factor 1 are anabolic hormones which play a vital role in developing body tracts especially in childhood and adolescence years. exercise is a motive which influences gh and igf-1 secretion. today, water sports are highly recommended due to creating delight in children. therefore, the purpose of this study was to examine the effect of eight weeks of water t...

The birefringence characteristics of reflection and transmission light pulse are explored in chiral medium driving by two probe electric magnetic fields, while four control fields. proposed shows significant behaviors reflection/transmission Goos-Hänchen (GH) shifted beams. birefringent GH-reflected GH-transmitted pulses show contribution the space time gap creation for secure communication inv...