BACKGROUND Pregnancy induced hypertension may indicate a tendency towards endothelial and metabolic abnormalities leading to future cardiovascular disease. Childhood socioeconomic adversity is associated with increased cardiovascular disease risk but the association with pregnancy induced hypertension is unknown. AIM To examine the association of childhood and adulthood socioeconomic position...

Background Women with polycystic ovary syndrome (PCOS) are at higher risk of developing pregnancy complications including gestational diabetes and preeclampsia. This study was performed with the aim of examining the impact of metformin on incidence of gestational diabetes and preeclampsia in pregnant women with PCOS. <s...

BACKGROUND We hypothesized that hemodynamic adaptations related to pregnancy and ageing might be associated with differences in blood pressure levels during pregnancy between younger and older women. This might partly explain the increased risk of gestational hypertensive disorders with advanced maternal age. We examined the associations of maternal age with systolic and diastolic blood pressur...

Rodents undergo gestational hepatomegaly to meet the increased metabolic demands on the maternal liver during pregnancy. This is an important physiological process, but the mechanisms and signals driving pregnancy-induced liver growth are not known. Here, we show that liver growth during pregnancy precedes maternal body weight gain, is proportional to fetal number, and is a result of hepatocyte...

A low-grade systemic inflammation is concomitant in diabetes. There is a pathophysiological relation between gestational diabetes mellitus and type 2 diabetes mellitus, which was further supported by significantly elevated risk of type 2 diabetes in women with a history of previous gestational diabetes mellitus. We investigated the relation between low-grade systemic inflammation expressed as C...

Pregnancy-induced hypertension is causing striking maternal, foetal and neonatal mortality and morbidity in the world. A case-control study was conducted on 113 women with gestational hypertension and 150 healthy pregnant women at Shahid Akbarabadi Hospital of obstetrics and gynaecology in south of Tehran. Women who were obese (OR 4.44; 95% CI 1.84-10.72) before pregnancy were more likely to de...

a bstract background: non‑medical utilization of pre‑implantation genetic diagnosis (pgd), like sex selection, is increasing, therefore it is necessary to follow‑up the health and outcome of fertilization and newborn’s birth followed pgd. the aim of this study was to evaluate the outcome of fertilization after sex selection by pgd and the relation between the age of parents and the outcome of f...

background: maternal nutrition during pregnancy affects the birth weight of neonates. some of the undesirable pregnancy outcomes are linked to lower birth weights. this study aimed to assess the relationship between maternal dietary patterns, weight gain during pregnancy and nitric oxide (no), as an endothelial relaxing factor, and the possible effects on birth weight.materials and methods: at ...

background: polycystic ovarian syndrome (pcos) is a complex hormonal disturbance that has numerous implications for general health and fertility. it is the most common cause of ovulatory disturbance, leading to infertility and probably, pregnancy loss. this study evaluated the complications and outcome of pregnancy in women with polycystic ovarian syndrome (pcos). methods: the course and outcom...

BACKGROUND Maternal obesity is accompanied by maternal and fetal complications during and after pregnancy. The risks seem to increase with degree of obesity. Leptin has been suggested to play a role in the development of obesity related complications. Whether maternal leptin levels differ between obese and morbidly obese women, during and after pregnancy, have to our knowledge not been previous...