Background The dosing of vancomycin and gentamicin relies largely on the weight and renal function of a patient. Due to their narrow therapeutic index, these drugs also require therapeutic drug monitoring (TDM) during treatment to ensure efficacy, reduce potential for otoand nephrotoxicity, and reduce potential for resistance. Guidelines for the use of vancomycin and gentamicin, as well as a do...

Hyrophila spinosa (H. spinosa) is used in folk medicine for various ailments and its different pharmacological activities have been reported. The present study was aimed at the evaluation of the nephrocurative and antioxidant effects of aqueous extract of H. spinosa against gentamicin (GM)induced nephrotoxicity. Male Sprague Dawley rats (200-250g) were treated with gentamicin at 80 mg/kg i.p. f...

CONTEXT Gentamicin is mainly used in severe infections caused by gram-negatives. However toxicity including nephrotoxicity and ototoxicity is one of the most important complications of its treatment. The production of free radicals seems to be involved in gentamicin toxicity mechanism. Taurine, a major intracellular free β-amino acid, is known to be an endogenous antioxidant. So potentially the...

The present study was carried out to evaluate the renoprotective antioxidant effect of Spirulina platensis on gentamicin-induced acute tubular necrosis in rats. Albino-Wistar rats, (9male and 9 female), weighing approximately 250 g, were used for this study. Rats were randomly assigned to three equal groups. Control group received 0,9 % sodium chloride intraperitoneally for 7 days at the same v...