In this work we have investigated the correlation existing between a short-term genotoxicity test (DNA repair in rat liver cells) and carcinogenicity in rodents. The work is in the framework of a line of thinking that considers as a possibility the utilization of the quantitative component of the information obtained from genotoxicity tests. In a preliminary report for 25 compounds belonging to...

The consumption of organic tomatoes (ORTs) reduces the risk of harmful effects to humans and the environment caused by exposure to toxic agrochemicals. In this study, we used the somatic mutation and recombination test (SMART) of wing spots in Drosophila melanogaster to evaluate the genotoxicity of ORT and the effect of cotreatment with ORT on the genotoxicity of Doxorubicin(®) (DXR, a cancer c...

This research is focused on determination of toxicity, genotoxicity and discovery of MTBE-degrading bacterial strains. Toxicity was detected using bacterial luminescent method Microtox while genotoxicity was monitored by Ames test with Salmonella typhimurium his (TA 98, TA 100, YG 1041 and YG 1042) as indicator strains. Potential MTBE-degrading strains were tested by Bioscreen. This method moni...

(1) Background: Desalination is a developing industry that keeps expanding, nowadays counting >15,000 infrastructures worldwide. A byproduct of the desalination process concentrated brine, further containing operational chemicals, including antiscalants and coagulants. Yet, potential genotoxic impacts inclusive brine are inadequately studied. (2) Methods: In vitro in vivo assays were used to...

Higher plants, an important material for genetic tests to monitor various pollutant present in the environment. Among the plant species, Alium cepa has been used to evaluate chromosome aberrations and disturbances in the mitotic cycle. Now days, it has been used to assess a great number of genotoxic/antigenotoxic agents, which contributes to its increasing application in environmental monitorin...

It is important for the prevention of DNA changes caused by environment to understand the biological consequences of DNA damages and their molecular modes of action that lead to repair or alterations of the genetic material. Numerous genotoxicity assay systems have been developed to identify DNA reactive compounds. The available data show that plant bioassays are important tests in the detectio...