Helichrysum sanguineum, Helichrysum pamphylicum, Helichrysum orientale, Helichrysum noeanum (Asteraceae) are medicinal plants. For centuries, they have been used as tea in Turkey because of their medicinal properties. So far no scientific evidence has been found in a literature survey regarding the genotoxic effects of these plants. This work evaluated the genotoxic effects on human lymphocyte ...

The circadian transcriptional repressors cryptochrome 1 (Cry1) and 2 (Cry2) evolved from photolyases, bacterial light-activated DNA repair enzymes. In this study, we report that while they have lost DNA repair activity, Cry1/2 adapted to protect genomic integrity by responding to DNA damage through posttranslational modification and coordinating the downstream transcriptional response. We demon...

OBJECTIVE Irinotecan is a botanical derivative and an anti-cancer drug with cytotoxic and genotoxic effects. The present study evaluated the effect of Lactobacillus plantarum A7 on the genotoxic activity of irinotecan in a hepatocellular carcinoma cell line (HepG2) by comet assay. MATERIALS AND METHODS HepG2 were incubated with irinotecan (100 µM), heat-killed cells (0.025 µg/ml) + irinotecan...

In this study, the onion (Allium cepa) root test was used to evaluate the genotoxicity of the Pitimbu River (Natal city, Brazil) surface water. The water was collected at five sampling sites along the river and one sample was obtained after the treatment (flocculation, chlorination and pH correction) of the river water for human consumption. All raw river water samples increased the frequency o...

OBJECTIVE To determine the in vitro toxicity of different concentrations of sevoflurane in cells exposed to X-ray. METHODS The genotoxic effects of sevofluorane were studied by means of the micronucleus test in cytokinesis-blocked cells of irradiated human lymphocytes. Subsequently, its cytotoxic effects on PNT2 (normal prostate) cells was determined using the cell viability test (MTT) and co...

HIGHLIGHTS Phenolic derivatives exert a genotoxic effect on the oral mucosa. The use of personal protective equipment and/or exhaust laminar flow hood reduces effects. Long-term exposure to agents can be measured by mucosa samples.

Citation: Coppi A, Lastrucci L, Cappelletti D, Cerri M, Ferranti F, Ferri V, Foggi B, Gigante D, Venanzoni R, Viciani D, Selvaggi R and Reale L (2018) AFLP Approach Reveals Variability in Phragmites australis: Implications for Its Die-Back and Evidence for Genotoxic Effects. Front. Plant Sci. 9:386. doi: 10.3389/fpls.2018.00386 AFLP Approach Reveals Variability in Phragmites australis: Implicat...

This speculation appears to be based solely on the range of variability of the various enzyme activities, as measured by in vitro analyses of enzyme kinetics, and does not take account of the abundant literature that deals with the metabolic and genotoxic consequences of these polymorphisms, as measured in human cells in vitro and metabolic and genotoxic biomarkers determined in vivo. The relev...