MicroRNAs (miRNAs) are key regulators in miRNA-mediated gene regulatory networks and play important roles in many biological processes, such as growth and development of mammals. In this study, we used microarrays to detect 261 miRNAs that are expressed in sheep skeletal muscle. We found 22 miRNAs that showed high levels of expression and equated to 89% of the total miRNA. Genetic variations in...

Chamomile serves as one of the most important medicinal plants. The most known secondary metabolites in chamomile species are volatile oils of triponoides, poly stilens, flavonoids and phenolic cafeic acid (Krori). These metabolites have wide variety of applications thanks to having medicinal properties of anti-inflammation, antispasmodic and bactericide activity. Also it is used to cure liver ...

Nuclear simple sequence repeats (nSSRs), together with 16 different enzyme loci, were used to analyzegenetic diversity and differentiation among beech (Fagus orientalis Lipsky) populations along two altitudinalgradients in Hyrcanian forests of Iran. Both enzymes and nSSR analyses revealed a high level ofgenetic diversity in natural populations of F. orientalis. The genetic div...

Genetic variations within the species of Agropyron desertorum and 2 varieties of A. cristatum subsp. pectinatum var. imbricatum and A. cristatum subsp. pectinatum var. pectinatum were studied using morphological traits and total protein profiles (with sodium dodecylsulphate polyacrylamide gel electrophoresis). An experiment was conducted in Research Institute of Forests and Rangelands (2012-201...

Numerous genetic variations have been found to be related to human diseases. Significant portion of those affect the drug response as well by changing the protein structure and function. Therefore, it is crucial to understand the trilateral relationship among genomic variations, diseases and drugs. We present the variations and drugs (VnD), a consolidated database containing information on dise...

Individual variability in drug efficacy and drug safety is a major challenge in current clinical practice, drug development, and drug regulation. For more than 5 decades, studies of pharmacogenetics have provided ample examples of causal relations between genotypes and drug response to account for phenotypic variations of clinical importance in drug therapy. The convergence of pharmacogenetics ...

BACKGROUND Chronic obstructive pulmonary disease (COPD) is a debilitating lung disease. To date, a large number of clinical studies have been conducted to investigate the association between genetic variations and COPD. However, little is known regarding the genetic susceptibility of Koreans to this disease. MER receptor tyrosine kinase (MERTK) plays important roles in the inhibition of inflamm...

OBJECTIVES Aetiological assessment of 71 probands whose clinical presentation suggested a genetic syndrome or auditory neuropathy. METHODS Sanger sequencing was performed on DNA isolated from peripheral blood or lymphoblastoid cell lines. Genes were selected for sequencing based on each patient's clinical presentation and suspected diagnosis. Observed DNA sequence variations were assessed for...