نتایج جستجو برای: genetic background

تعداد نتایج: 1398542  

Journal: :Expert review of clinical immunology 2011
Jasper C A Broen Marieke J H Coenen Timothy R D J Radstake

Systemic sclerosis (SSc) is a severe autoimmune connective tissue disease. Over the years, evidence for a genetic background of SSc susceptibility has clearly accumulated. This article aims to provide an extensive overview of genetics in SSc research. We discuss indicators for a genetic component present in SSc, family studies, chromosomal aberrances, the involvement of the HLA region and multi...

2005
Alexander V. Favorov Timophey V. Andreewski Marina A. Sudomoina Olga O. Favorova Giovanni Parmigiani Michael F. Ochs

In recent years, the number of studies focusing on the genetic basis of common disorders with a complex mode of inheritance, in which multiple genes of small effect are involved, has been steadily increasing. An improved methodology to identify the cumulative contribution of several polymorphous genes would accelerate our understanding of their importance in disease susceptibility and our abili...

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