Objective(s): It is known that extremely low frequency-pulsed electromagnetic fields (ELF-PEMF) influence multiple cellular and molecular processes. Retinal pigment epithelial (RPE) cells have a significant part in the emergence and pathophysiology of several ocular disorders, such as neovascularization. This study assessed the impact of ELF-PEMF on the proangiogenic features of RPE cells. Mate...

objective: in this paper, we have introduced topoisomerase inhibitors, mechanism of action and types of them. dna topoisomerases are ubiquitous enzymes that catalyze essential enzymes to solve the topological problems accompanying key nuclear processes such as dna replication, transcription, repair and chromatin assembly by introducing temporary single or double strand breaks in the dna. result...

insect growth regulators and spinosyns which are physiologically and ecologically selective, respectively, have been investigated as replacements or complements to non-selective conventional insecticides. the effects of diflubenzuron, hexaflumuron, profenofos, spinosad and thiodicarb were assessed on the 1st instars of cotton bollworm, helicoverpa armigera (hã¼bner) using dietary and leaf disc ...

abstract        background and objective: peroxidases catalyze protein oxidation and lipid peroxidation. the activity of these enzymes in nerve cells is involved in causing disorders such as alzheimer's and parkinson's disease. this study investigated the effect of citrus aurantium, foeniculum vulgare and rosmarinus officinalis essential oils on activity of peroxidase enzyme.       me...

histone deacetylases (hdacs) are the enzymes causing deacetylation of histone and non-histone substrates. histone deacetylase inhibitors (hdis) are a family of drugs eliminating the effect of hdacs in malignant cells via inhibition of hdacs. due to extensive effects upon gene expression through interference with fusion genes and transcription factors, hdacs cause proliferation and migration of ...

Acetylation of histones in chromatin is one mechanism involved in the regulation of gene transcription and is tightly controlled by the balance of acetyltransferase and deacetylase (HDAC) activities. In cancer, some genes are repressed by the inappropriate recruitment of HDACs, e.g., tumor suppressor genes. To understand the genomic effects of HDAC inhibition on gene transcription we studied th...

Aromatase inhibitors have played a central role in endocrine therapy for estrogen receptor (ER)-positive breast cancer in postmenopausal women. However, factors predictive of the efficacy of aromatase inhibitors, and prognostic factors, both for early and late recurrence in women treated with adjuvant aromatase inhibitors have not been identified. Whole genome analysis identified that a TP53 ge...

Hepatocellular carcinoma (HCC) is a public health problem in developing countries where chronic HBV endemic. The objective of our study was to determine the prevalence KRAS and BRAF mutations patients with HCC. Mutations codons 12 13 V600E mutation gene were searched by HRM on Light Cycler 480 confirmed direct sequencing. A total 34 HCC underwent molecular testing for codon gene. Melting curve ...

Abstract BACKGROUND Glioblastoma (GBM) is the most aggressive and lethal type of brain tumor. Activation PI3K/mTOR pathway along with loss its primary negative regulator, phosphatase tensin homolog (PTEN), occurs in nearly 50% GBM patients. As PTEN known to promote DNA damage repair deficiency, here we investigated whether deficiency presents a vulnerability simultaneous induction suppression m...

We have previously reported that NS-398, a cyclooxygenase-2 (COX-2)-selective inhibitor, inhibited replicative cellular senescence in human dermal fibroblasts and skin aging in hairless mice. In contrast, celecoxib, another COX-2-selective inhibitor, and aspirin, a non-selective COX inhibitor, accelerated the senescence and aging. To figure out causal factors for the senescence-modulating effec...