Dosage compensation, mediated by the MSL complex, regulates X-chromosomal gene expression in Drosophila. Here we report that the histone H4 lysine 16 (H4K16) specific histone acetyltransferase MOF displays differential binding behavior depending on whether the target gene is located on the X chromosome versus the autosomes. More specifically, on the male X chromosome, where MSL1 and MSL3 are pr...

A direct relation between gene dosage and amount of the corresponding protein is generally assumed to exist though it has been investigated in a limited number of cases. Yeasts seem to be an ideal material for this type of investigation as they can be easily obtained in different degrees of ploidy. Macromolecular components of yeast cells in polyploid series have been already determined (OGUR e...

Following the suppression of recombination, gene expression levels decline on the sex-limited chromosome, and this can lead to selection for dosage compensation in the heterogametic sex to rebalance average expression from the X or Z chromosome with average autosomal expression. At the same time, due to their unequal pattern of inheritance in males and females, the sex chromosomes are subject t...