نتایج جستجو برای: gelatinases

تعداد نتایج: 2269  

Journal: :American journal of physiology. Lung cellular and molecular physiology 1999
Hussein D Foda Suni George Ellen Rollo Michelle Drews Cathleen Conner Jian Cao Reynold A Panettieri Stanley Zucker

Matrix metalloproteinases (MMPs) play an important role in tumor metastasis and invasion, inflammatory tissue destruction and remodeling, wound healing, and angiogenesis. The 72-kDa gelatinase A is the most widely distributed of all the MMPs, and along with the 92-kDa gelatinase B, both play an important role in the turnover of basement membrane. The role of MMPs in chronic airway inflammation ...

Journal: :Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2006
Ruth Oltenfreiter Ludovicus Staelens Veerle Kersemans Bart Cornelissen Francis Frankenne Jean-Michel Foidart Christophe Van de Wiele Guido Slegers

Among matrix metalloproteinases (MMPs), the subfamily of gelatinases (MMP-2, MMP-9) is of particular interest due to their ability to degrade type IV collagen and other non-fibrillar collagen domains and proteins such as fibronectin and laminin. Whilst malignant cells often over-express various MMPs, the gelatinases have been most consistently detected in malignant tissues and associated with t...

Journal: :Molecular pharmacology 2012
Athira Omanakuttan Jyotsna Nambiar Rodney M Harris Chinchu Bose Nanjan Pandurangan Rebu K Varghese Geetha B Kumar John A Tainer Asoke Banerji J Jefferson P Perry Bipin G Nair

Cashew nut shell liquid (CNSL) has been used in traditional medicine for the treatment of a wide variety of pathophysiological conditions. To further define the mechanism of CNSL action, we investigated the effect of cashew nut shell extract (CNSE) on two matrix metalloproteinases, MMP-2/gelatinase A and MMP-9/gelatinase B, which are known to have critical roles in several disease states. We ob...

Journal: :Journal of cell science 1994
P A Hill G Murphy A J Docherty R M Hembry T A Millican J J Reynolds M C Meikle

We have compared the effects of a general matrix metalloproteinase (MMP) inhibitor (CT435) with those of a concentration-dependent specific gelatinase inhibitor (CT543; Ki < 20 nM) on bone resorption in vitro. The test systems consisted of measuring: (i) the release of 45Ca2+ from prelabelled mouse calvarial explants; (ii) the release of 45Ca2+ from prelabelled osteoid-free calvarial explants c...

2013
Renpan Zeng Feng Wen Xiongze Zhang Yu Su

PURPOSE Age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) are the leading causes of vision loss in the elderly Asian population. Previous studies have confirmed that abnormal extracellular matrix (ECM) metabolism plays an important role in the pathogenesis of AMD and PCV. However, the dynamic metabolism of the ECM is closely regulated by matrix metalloproteinase...

Journal: :Journal of the American Society of Nephrology : JASN 2001
B Legallicier G Trugnan G Murphy B Lelongt P Ronco

Type IV collagenases matrix metalloproteinase-2 (MMP2) and MMP9 and their related proteins, MT1-MMP, tissue inhibitor of metalloproteinases 1 (TIMP1), TIMP2, and TIMP3, are expressed during kidney morphogenesis and nephrogenesis, but the renal ontogeny of these proteins is only partially known, and their persistence in the adult remains controversial. Their expression was analyzed from early me...

Journal: :Haematologica 2010
Marta Segarra Ester Lozano Marc Corbera-Bellalta Carme Vilardell Maria-Teresa Cibeira Jordi Esparza Nora Izco Joan Bladé Maria C Cid

BACKGROUND Thalidomide and its analogs are effective agents in the treatment of multiple myeloma. Since gelatinases (matrix metalloproteinases-2 and -9) play a crucial role in tumor progression, we explored the effect of thalidomide on gelatinase production by malignant B lymphoid cell lines. DESIGN AND METHODS We investigated the effect of therapeutic doses of thalidomide on integrin-mediate...

2013
Danielle Queiroz Calcagno Vanessa Morais Freitas Mariana Ferreira Leal Carolina Rosal Teixeira de Souza Samia Demachki Raquel Montenegro Paulo Pimentel Assumpção André Salim Khayat Marília de Arruda Cardoso Smith Andrea Kely Campos Ribeiro dos Santos Rommel Rodriguez Burbano

BACKGROUND MYC deregulation is a common event in gastric carcinogenesis, usually as a consequence of gene amplification, chromosomal translocations, or posttranslational mechanisms. FBXW7 is a p53-controlled tumor-suppressor that plays a role in the regulation of cell cycle exit and reentry via MYC degradation. METHODS We evaluated MYC, FBXW7, and TP53 copy number, mRNA levels, and protein ex...

Journal: :Journal of neurosurgery 2003
Staci Goussev Jung-Yu C Hsu Yong Lin Tjoson Tjoa Nino Maida Zena Werb Linda J Noble-Haeusslein

OBJECT Matrix metalloproteinases (MMPs), particularly MMP-9/gelatinase B, promote early inflammation and barrier disruption after spinal cord injury (SCI). Early blockade of MMPs after injury provides neuroprotection and improves motor outcome. There is recent evidence, however, that MMP-9 and MMP-2/gelatinase A participate in later wound healing in the injured cord. The authors therefore exami...

Journal: :Pharmacological reports : PR 2009
Agnieszka Madro Jacek Kurzepa Grazyna Czechowska Maria Słomka Krzysztof Celiński Stanisława Szymonik-Lesiuk

Matrix metalloproteinase (MMP)-2 and -9 (gelatinases) participate in extracellular protein remodeling. Moreover, they are involved in the development of hepatic fibrosis. The goal of this study was to evaluate liver gelatinase activities after erythropoietin (Epo) treatment (1U/dose, sc) in experimentally damaged livers of rats treated with D-galactosamine (Gal, 800 mg/kg/dose, ip). Sixty rats ...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید