BACKGROUND Urinary leukotriene (LTE4) is an important marker of airway inflammation presence. A relationship between single nucleotide polymorphism in the glucocorticoid receptor (GCR) gene promoter (Bcl I polymorphism), development of asthma and sensitivity to glucocorticoids has been hypothesised. OBJECTIVE To explore the possible association between the Bcl I polymorphism and baseline leve...

In order to elucidate the mechanism of latent infection of herpes simplex virus (HSV), reactivatable latency of three avirulent strains (SKO-1B, -GCr Miyama, SKa) of HSV type 1 was comparatively examined in a mouse latency model. The SKO-1B strain showed high rate of virus reactivation from explanted trigeminal ganglia without n-butyrate enhancement, while the other two strains showed a very lo...

OBJECTIVES To measure urine concentrations of sulfated glycosaminoglycans (GAGs), determine optimal storage conditions for urine samples, establish a reference range, and determine whether there is correlation between 24-hour total urine GAG excretion and the GAG-to-creatinine ratio (GCR). ANIMALS 14 healthy adult dogs. PROCEDURE Single urine sample GAG concentrations and GCRs were measured...

1293, 2001; [5] Jun I., JPL, pers. comm., 2002; [6] Hahn et al., IEEE Trans. Nuc. Sci., submitted, 2002; [7] Waters, MCNPX Users Manual, LA-UR 02-2607, 2002. Figure 1. Schematic diagram of the NS, rover, and Martian surface model used for this study. Figure 2. Epithermal neutrons (counts per second) versus H2O content for the bottom dry layer. Black and left scale are for the RTG case; red and ...

We present a quantitative model of galactic cosmic ray (GCR) origin and acceleration, wherein a mixture of interstellar and/or circumstellar gas and dust is accelerated by a supernova remnant (SNR) blast wave. The gas and dust are accelerated simultaneously, but differences in how each component is treated by the shock leaves a distinctive signature which we believe exists in the cosmic ray com...

Glucocorticoid resistance (GCR), i.e. unresponsiveness to the beneficial anti-inflammatory activities of the glucocorticoid receptor (GR), poses a serious problem in the treatment of inflammatory diseases. One possible solution to try and overcome GCR, is to identify molecules that prevent or revert GCR by hyper-stimulating the biological activity of the GR. To this purpose, we screened for com...

This study set out to explore whether different input enhancement tasks as implicit instruction techniques had any significant impact on the intake of causative verbs in English as a foreign language among Iranian EFL learners. For this purpose, three intact classes consisting of 75 male and female intermediate L2 learners were randomly divided into three conditions: simultaneous grammar consci...

<p style="text-align: justify;">The primary goal of this study is to explore what makes teachers accept Google Classroom (GCR). GCR platform an emerging technology that could support online learning activities by offering outstanding benefits such as usability, flexibility, and task adaptability. Many the students in Indonesia have al-ready used since government has tried provide it a fre...

OBJECTIVE Mifepristone, a glucocorticoid receptor antagonist, improves clinical status in patients with Cushing's syndrome (CS). We examined the pattern, reliability and correlates of global clinical response (GCR) assessments during a 6-month clinical trial of mifepristone in CS. DESIGN Post hoc analysis of secondary end-point data from a 24-week multicentre, open-label trial of mifepristone...

Glucocorticoid (GCs) hormones are widely used in the treatment of bronchial asthma. However, not all aspects of their pharmacological effects are well understood as yet. It is know that the effects of GCs are mediated through GC receptors (GCRs). We sought to evaluate the effect of short-term and chronic GC therapy on GCR number in peripheral blood lymphocytes, the relationship between GCR numb...