نتایج جستجو برای: gated sodium channel vgsc
تعداد نتایج: 412203 فیلتر نتایج به سال:
In the present study, we designed and conducted a series of assays to determine the expression of voltage-gated sodium channel (VGSC) neonatal isoform Nav1.5 (nNav1.5) in human brain astrocytoma and its effect on the proliferation, migration, invasion and apoptosis of astrocytoma U251 cells. The results showed that nNav1.5 mRNA and protein were expressed in both human brain astrocytoma and norm...
BACKGROUND The growing applications of nanotechnologic products, such as quantum dots (QDs), increase the likelihood of exposure. Furthermore, their accumulation in the bioenvironment and retention in cells and tissues are arousing increasing worries about the potentially harmful side effects of these nanotechnologic products. Previous studies concerning QD cytotoxicity focused on the reactive ...
The sodium "channelopathies" are the first among the ion channel diseases identified and have attracted widespread clinical and scientific interests. Human voltage gated sodium channels are sites of action of several antiarrhythmic drugs, local anesthetics and related antiepileptic drugs. The present study aims to optimize the activity of Disopyramide, by modification in its structures which ma...
Abstract Epilepsy is a neurological disease characterized by excessive and abnormal hyper-synchrony of electrical discharges the brain predisposition to generate epileptic seizures resulting in broad spectrum neurobiological insults, imposing psychological, cognitive, social also economic burdens sufferer. Voltage-gated sodium channels (VGSCs) are essential for generation propagation action pot...
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