BACKGROUND Global DNA hypomethylation has been found in the premalignant stages of some neoplasms and has been implicated as an important factor for tumour progression. AIMS The aim of this study was to evaluate whether DNA hypomethylation occurs during the process of gastric carcinogenesis. METHODS Gastric specimens were obtained from 49 patients and histologically classified as: normal 10...

Our experience with laparoscopy in the diagnosis and staging of 23 cases of pancreatic cancer is reported. This endoscopic procedure has proved useful in the diagnosis of the disease, in the assessment of operability, and in the retrieval of material for histological and cytological confirmation of pancreatic cancer. An infra-gastric laparoscopic method for inspection of the body and tail of th...

Secondary malignant neoplasms are important late complications after chemotherapy and/or radiotherapy in cancer patients. Therapy‐related malignancies include acute leukemia, myelodysplastic syndrome (MDS), lymphoma, and solid tumors. However, secondary acute lymphoid leukemia or chronic myeloid leukemia (CML) is rarely reported.[1] Here, we present a patient with P190BCR‐ABL‐positive CML follo...

Gastroduodenal intussusception is an infrequent cause of gastrointestinal obstructive disease. Benign neoplasms, gastrointestinal stromal tumors and pedunculated adenocarcinomas of less than 5 cm have been reported to cause gastroduodenal intussusception. We report a case of 76-year-old woman who was presented with a 3-day history of nausea and vomiting due to upper gastrointestinal obstruction...

Gastrointestinal stromal tumors (GIST) are rare neoplasms that mostly affect patients over the age of 50, with no gender predilection1,2. The diagnosis of GIST is made by means of immunohistochemistry testing for CD117 (c-kit), and combination treatment with surgical intervention and adjuvant chemotherapy has produced good outcomes3. We report a case of gastric GIST diagnosed after an episode o...