Despite the unprecedented popularity of separation chromatography, the measurement of coeluting isomeric chemicals remains an extremely difficult task. We developed an analytical scheme capable of measuring two coeluting isomers using a single chromatographic column and a gas chromatography/tandem mass spectrometry system. The protocol utilized two product ion fragments generated from a common ...

The Mario Negri Institute has largely contributed in its many years to the development of pharmacokinetics, introducing new analytical techniques such as gas and liquid chromatography combined or not with mass spectrometry.(Sottani C, et al. Structural characterization of monoand dihydroxylated metabolites of paclitaxel in rat bile using liquid chromatography/ion spray tandem mass spectrometry....

Comprehensive two-dimensional gas chromatography can be viewed as a traditional gas chromatography with a sophisticated "elution-resolved" flame ionization detector (GC/FID) or a detector with separation capability. The concept of multidimensional chromatography can be extended to other detectors that also have separation capability, such as ultraviolet, infrared, and mass spectrometer. Mass sp...

a headspace-solid phase microextraction (hs-spme) and gas chromatography-mass spectrometry (gc-ms) method has been developed for the simultaneously determination of 20 disinfection by-products (dbps) in water samples from reverse osmosis (ro) membranes. selected compounds belong to different families including: trihalomethanes (thms), halogenated acetonitriles (hans), halogenated nitromethanes ...

An unknown guanidino-positive peak has been identified in urines of three sisters affected with hyperargininaemia. Identification was made on the basis of its similarity with the liquid and thin-layer chromatographic characteristics of enzymatically synthesized 2-oxo-5-guanidinovaleric acid. Identification was also made by combined gas chromatography-mass spectrometry of the unknown compound pe...

In a previous study, selective degradation of carbohydrates versus lignin in buried woods was demonstrated by non-destructive spectroscopy (C NMR) and destructive wet chemical methods (acid hydrolysis and alkaline CuO oxidation). In this paper, spruce, alder and oak woods deposited in coastal sediments and their recent equivalents are characterized by pyrolysis-mass spectrometry and pyrolysis-g...

Sample Types LC/MS systems facilitate the analysis of samples that traditionally have been difficult to analyze. Despite the power and usefulness of gas chromatography/mass spectrometry (GC/MS), many compounds are impossible to analyze with GC/MS. LC/MS significantly expands the effective analytical use of mass spectrometry to a much larger number of organic compounds. Gas chromatography and GC...