2120 CLINICAL CHEMISTRY, Vol. 40, No. 11, 1994 we reported here, we overcome this problem by using the filters. We have not observed any late-eluting peaks that would interfere with the subsequent chromatogram nor any reduction in column life attributable to sample contamination. Moreover, the results we obtained with the amperometric detector are comparable with those of the coulometric detector.

Abbreviations: LLOQ: Lower Limit of Quantification; QC: Quality Control; LQC: Low QC; MQC: Middle QC; HQC: High QC; SPE: Solid Phase Extraction; MRM: Multiple Reaction Monitoring; CV: Coefficient of Variation; RE: Relative Error; QqTOF: Quadrupole-QuadrupoleTime-Of-Flight; FDA: Food and Drug Administration; EMA: European Medicines Agency; XIC: Extracted-Ion Chromatogram; AUC: Area under the Cur...

Mutagenic activity was found in the urine of 10 patients given therapeutic dosages of metronidazole orally or per vagina. Paper chromatographic separation revealed that mutagenicity in the urine was associated with unmodified metronidazole and at least four of its known urinary metabolites. Activity was also recovered in a region of the chromatogram heretofore not assigned to a metronidazole me...

Automated DNA sequencers generate chromatograms that contain raw sequencing data. They also generate data that translates the chromatograms into molecular sequences of A, C, G, T, or N (undetermined) characters. Since chromatogram translation programs frequently introduce errors, a manual inspection of the generated sequence data is required. As sequence numbers and lengths increase, visual ins...

Chromatographic, ultracentrifugal, and related studies of the fibrinogen of a patient with a congenital disorder of fibrinogen (fibrinogen "Baltimore" have provided evidence of structural differences from normal.Diethylaminoethyl-cellulose (DEAE-cellulose) gradient elution chromatography demonstrated two major peaks in the elution pattern of fibrinogen Baltimore as was the case for normal fibri...

In this paper, we report on a printable glass-based manufacturing method and new proof-of-concept colorimetric signal readout scheme for dielectric barrier discharge (DBD)-type helium plasma photoionization detector. The sensor consists of millimeter-sized glass chamber manufactured using suspension. Plasma inside the chip is generated custom-built power supply (900 V 83.6 kHz), detector uses ∼...

Shea press cake is a subproduct of shea butter production. It generally serves as animal food or fuel, in areas. This study demonstrated its ability edible organic bank bioactive molecules useful for human. Therefore, the hydroalcoholic extract was screened through GC-MS analysis, and antinutritional compounds were quantified. Chromatogram revealed wide range belonging to various famillies. Hen...