نتایج جستجو برای: ganglioside
تعداد نتایج: 3543 فیلتر نتایج به سال:
Glycosphingolipids are ubiquitous constituents of eukaryotic plasma membranes, and their sialylated derivatives, gangliosides, are the major class of glycoconjugates expressed by neurons. Deficiencies in their catabolic pathways give rise to a large and well-studied group of inherited disorders, the lysosomal storage diseases. Although many glycosphingolipid catabolic defects have been defined,...
The ability to induce T-cell apoptosis is one mechanism by which tumors evade the immune system, although the molecules involved remain controversial. We found that renal cell carcinoma (RCC)-induced T-cell apoptosis was inhibited by >50% when cocultures were performed with ganglioside-depleted tumor cells, caspase-8-negative lymphocytes, or anti-tumor necrosis factor-alpha (TNFalpha) antibodie...
The diagnosis and severity of Parkinson's disease are established by clinical criteria. motor manifestations predominate while few sensory. Initially, treatment includes dopaminergic drugs and/or agonists with good results in the first years. Later symptoms appear requiring different therapeutic strategies. Here, we present a series patients late fluctuations treated monosialo-ganglioside. Seve...
Clostridium Botulinum Type E neurotoxin heavy chain consists of two domains: the translocation domain asthe N-terminal half and the binding domain as the Cterminal half (Hc). One effective way to neutralize botulinum neurotoxin is to inhibit binding of this toxin to neuromuscular synapses with antibodies against binding domain. Two synthetic genes, coding for Hc (the full length binding d...
The GD2 ganglioside expressed on neuroectodermally derived tumors, including neuroblastoma and melanoma, is weakly immunogenic in tumor-bearing patients and induces predominantly immunoglobulin (Ig)-M antibody responses in the immunized host. Here, we investigated whether interconversion of GD2 into a peptide mimetic form would induce GD2 cross-reactive IgG antibody responses in mice. Screening...
1. GM,-ganglioside, specifically tritiated in the terminal galactose, was hydrolysed by two forms of 'acid' methylumbelliferyl fl-galactosidase isolated on gel filtration. 2. Identification of GM1-ganglioside ,B-galactosidase activity with the 'acid' methylumbelliferyl ,-galactosidases was based on the following: coincident elution profiles on gel filtration; simultaneous inactivation by heat a...
Guillain-Barré syndrome (GBS) is a monophasic immune neuropathic disorder in which a significant proportion of patients have incomplete recovery. The patients with incomplete recovery almost always have some degree of failure of axon regeneration and target reinnervation. Anti-ganglioside antibodies (Abs) are the most commonly recognized autoimmune markers in all forms of GBS and specific Abs a...
Exogenous gangliosides at concentrations found in Se muminhibit the concanavalin A(Con A) induced mitogenic response of mouse thymocytes. Of four gangliosides tested, the tnisialoganglioside, °T1'was the most potent inhibitor. Cemamides,cemebmosides,and sialic acid were not inhibitory at any concentration tested. The inhibition by gangliosides was not due to interference with Con A binding as ...
II3NeuAc-GgOse4Cer (GM1) gangliosidosis is an incurable lysosomal storage disease caused by a deficiency in acid beta-galactosidase (beta-gal), resulting in the accumulation of ganglioside GM1 and its asialo derivative GgOse4Cer (GA1) in the central nervous system, primarily in the brain. In this study, we investigated the effects of N-butyldeoxygalacto-nojirimycin (N B-DGJ), an imino sugar tha...
The effects of mucin on cholera toxin induced intestinal secretion was studied in the rat small intestine. Gastric mucin inhibited secretion when premixed with cholera toxin on an equal dry-weight basis. Neither salivary nor intestinal mucin inhibited the toxin's action in the intestine. Inhibition by gastric mucin was not reversed by a mucolytic agent or by hexoses or agents that bind hexoses....
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