Background Each year breast cancer is diagnosed in approximately 1 million women worldwide [1]. Our lab has previously linked Junctional Adhesion Molecule A (JAM-A) gene and protein over-expression in breast tumours with an increased risk of metastasis [2,3]. JAM-A loss or inhibition has also been shown to inhibit cell migration and invasion [2], while increasing apoptosis possibly as a result ...

The junctional adhesion molecule B (JAM-B) is a multifunctional transmembrane protein, which belongs to the immunoglobulin superfamily (IgSF). JAM-B is localized to cell-cell contacts and enriched at cell junctions in epithelial and endothelial cells, as well as on the surface of erythrocytes, leukocytes, and platelets. Recent research in this field has shown that JAM-B plays an important role ...

A detailed study is undertaken of the v{max}=1 limit of the cellular automaton traffic model proposed by Nagel and Paczuski [Phys. Rev. E 51, 2909 (1995)]. The model allows one to analyze the behavior of a traffic jam initiated in an otherwise freely flowing stream of traffic. By mapping onto a discrete-time queueing system, itself related to various problems encountered in lattice combinatoric...

Monocyte recruitment from the vasculature involves sequential engagement of multiple receptors, culminating in transendothelial migration and extravasation. Junctional adhesion molecule-C (JAM-C) is localized at endothelial intercellular junctions and plays a role in monocyte transmigration. Here, we show that blockade of JAM-B/-C interaction reduced monocyte numbers in the extravascular compar...

The Developed in 2006 the IGDA EdSIG mission is to create a community resource that will strengthen the academic membership of the IGDA while enhancing the education of future and current game developers. Since the inception of the SIG there have been two major projects: 1) 2008 IGDA Curriculum Framework which has become the standard for game education; 2) The Global Game Jam where experimentat...

This paper investigates handover and fresh call blocking probabilities for subscribers moving along a road in a traffic jam passing through consecutive cells of a wireless network. It is observed and theoretically motivated that the handover blocking probabilities show a sharp peak in the initial part of a traffic jam roughly at the moment when the traffic jam starts covering a new cell. The th...