Elevated interstitial fluid pressure (IFP) in tumors can cause metastatic dissemination and treatment resistance, but its study poses a challenge because of a paucity of noninvasive imaging strategies. In this study, we address this issue by reporting the development of a noninvasive tool to assess tumor IFP and interstitial hypertension-induced lymph node metastasis. Using mouse xenograft mode...

The objective of this study was to evaluate the Role of MRU as a single imaging modality in evaluation of Pelvi-ureteric junction obstruction. 40 patients of hydronephrosis suspected to have PUJ obstruction were enrolled for the study from May 2010 to Nov. 2012. All patients under went USG, intravenous Urography (IVU), Glomerular filtration rate (GFR) Calculation by Cockcroft-Gault formula and ...

Laser atomic magnetometry is a portable and low-cost yet highly sensitive method for low magnetic field detection. In this work, the atomic magnetometer was used in a remote-detection geometry to measure the relaxivity of aqueous gadolinium-diethylenetriamine pentaacetic acid Gd(DTPA) at the Earth's magnetic field (40 μT). The measured relaxivity of 9.7±2.0 s(-1) mM(-1) is consistent with field...

Introduction: An arterial input function (AIF), plasma concentration versus time curve, for an MR contrast agent (MRCA) is used to estimate the blood–brain barrier (BBB) permeability of microvessels and several other vascular related parameters. In dynamic contrast-enhanced MRI (DCE-MRI), an intravenous step-down infusion (SDI) procedure that maintains a constant gadolinium-diethylenetriaminepe...

BACKGROUND Several late sequelae of the administration of gadolinium (Gd)-containing MRI contrast agents have been described in patients with advanced renal failure. In an observational series, we found a remarkable frequency of peracute reactions after administration of Gd-DTPA used for cardiovascular evaluation before renal transplantation. METHODS In a 26-month observational period, 13 of ...

Lanthanide gadolinium (Gd(3+)) blocks Ca(V)1.2 channels at the selectivity filter. Here we investigated whether Gd(3+) block interferes with Ca(2+)-dependent inactivation, which requires Ca(2+) entry through the same site. Using brief pulses to 200 mV that relieve Gd(3+) block but not inactivation, we monitored how the proportions of open and open-blocked channels change during inactivation. We...

Department of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons-Hainaut, 24, Avenue du Champ de Mars, B-7000 Mons, Belgium; Laboratory of Radiopharmacy, Department of Pharmaceutical Sciences, Catholic University of Louvain, Onderwijs en Navorsing 2, Box 821, B-3000 Leuven, Belgium; and Department of Histology, University of Mons-Hainaut, 24, Ave...

Gadolinium (Gd) neutron capture plays an important role in both Gd neutron capture therapy and neutron detection. Detailed information about the lowenergy electron spectrum emitted after Gd neutron capture is essential for accurately determining the dose delivery to the target and healthy tissues, as well as the effectiveness of Gd against other neutron convertors such as boron (B) and lithium ...

MR imaging can provide cross-sectional images in multiple imaging planes with equal resolution and improve localization of abnormal tissue over that afforded by CT [1, 2]. MRdirected biopsy of the body has already been safely performed [3]; however, MR-directed biopsy of the brain is potentially more difficult and risky because of the problems involved in identifying possible intracranial hemor...

The stability and water exchange dynamics of gadolinium (GdIII) complexes are critical characteristics that determine their effectiveness as contrast agents for magnetic resonance imaging (MRI). A new heteropodal GdIII chelate, [Gd-TREN-bis(6-Me-HOPO)-(TAM-TRI)(H2O)2] (Gd-2), is presented which is based on a hydroxypyridinate (HOPO)-terephthalamide (TAM) ligand design. Thermodynamic equilibrium...