UNLABELLED In this study, we examined the effect of intrathecal (i.t.) gabapentin, administered before and after the injection of formalin into the rat hindpaw, on pain behavior and hemodynamics. Formalin evoked a biphasic flinching behavior and hypertension. I.t. gabapentin administered 10 min before formalin produced a dose-dependent reduction of the Phase 2, but not Phase 1, flinching and ca...

OBJECTIVE To report the use of gabapentin in the treatment of behavioral and psychological symptoms of dementia (BPSD) and to review the available literature relating to the use of gabapentin in this population. CASE SUMMARY A 62-year-old white man was admitted to the hospital due to a worsening state of confusion, anxiety, depressed mood, insomnia, and verbal and physical aggressiveness towa...

The objective of this study was to determine the efficacy of gabapentin as adjunctive therapy in doses required to achieve the most effective seizure control. There were 2016 patients with partial seizures requiring adjunctive therapy who received gabapentin at doses up to 3600 mg/day in this open-label, multicenter, 16-week study. Of the 1055 patients evaluable for efficacy, 573 received gabap...

Gabapentin is a well-established anticonvulsant drug which is also effective for the treatment of neuropathic pain. Although the exact mechanism leading to relief of allodynia and hyperalgesia caused by neuropathy is not known, the blocking effect of gabapentin on voltage-dependent calcium channels has been proposed to be involved. In order to further evaluate its analgesic mechanisms, we teste...

BACKGROUND Perioperative pain treatment often consist of combinations of non-opioid and opioid analgesics, 'multimodal analgesia', in which gabapentin is currently used. The aim was to document beneficial and harmful effects of perioperative gabapentin treatment. METHODS Randomized clinical trials comparing gabapentin vs. placebo or active placebo in adult surgical patients receiving gabapent...

Gabapentin has become increasingly used in psychiatric practice specifically for anxiety disorders. Even though gabapentin is not approved by the US Food and Drug Administration to treat anxiety, physicians sometimes use it as an alternative to benzodiazepines in patients with a history of substance abuse. Gabapentin is also prescribed when individuals are at risk of thrombocytopenia which is n...

The abuse potential of drugs that stimulate dopamine release has driven the search for drugs that influence alternate neurotransmitters, and the glutaminergic pathway is a potential target for the development of new therapeutic practices [1]. Gabapentin is one such drug that modulates GABA and glutamate levels; its clinical effectiveness has been reported across a wide variety of disorders rang...

The effect of gabapentin on cognition and quality of life (QoL) in patients with epilepsy was investigated using a controlled pre- and post-treatment design. Thirty patients with chronic epilepsy were administered a battery of cognitive tests and QoL measures at baseline (pre-treatment) and again following 1-2 months of treatment (post-treatment). All patients were receiving anticonvulsant medi...

introduction: hot flash affects approximately 75% of women with breast cancer. those who experience hot flashes have higher rates of sleep disorders, temper and lower quality of life than women with no hot flashes. the   persent   study   was aimed to compare the effect of megestrol acetate with gabapentin on the severity of hot flashes in patients with breast cancer materials and methods: in a...

Gabapentin and Nortriptyline are used to treat neuropathic pain. belongs a group of drugs called anti-convulsant tricyclic antidepressant. acts by binding the specific site on voltage- gated calcium channels. This helps in relieving nerve pain lowers risk seizure. works preventing released chemical messengers brain (serotonin norepinephrine) from being reabsorbed back into cells. As result, it ...