نتایج جستجو برای: g4
تعداد نتایج: 3745 فیلتر نتایج به سال:
INTRODUCTION It has been reported that immunoglobulin G4-related systemic disease can spread to nearly every organ, and often presents as an inflammatory mass or masses at those sites. In the kidney, this disease is often diagnosed after a radical or partial nephrectomy following the discovery of an inflammatory mass which is often suspected to be a malignant tumor. Here, we present a rare case...
A sensitive and selective amperometric sensing platform for lead (Pb(2+)) was developed based on a Pb(2+)-induced G-rich DNA conformational switch from a random-coil to G-quadruplex (G4) with crystal violet as the G4-binding indicator.
زمینه و هدف: هدف از این مطالعه بررسی اثر ضد باکتریایی دندریمر پلی آمیدوآمین–g4 بر باکتری های اشرشیاکلی، آنتروباکتر کلواکه، باسیلوس سوبتیلیس و استافیلوکوکوس اورئوس می باشد. مواد و روش ها: در این مطالعه تجربی اثرات ضد باکتریایی دندریمر پلی آمیدوآمین–g4 به روش انتشار دیسک و رقت لوله ای بررسی شد. غلظت های مختلفی از دندریمر پلی آمیدوآمین-g4 بر روی دیسک های بلانک تلقیح شده و در محیط کشت مولر هینتون آ...
G-quadruplexes (G4) are stacked non-canonical nucleic acid structures found in specific G-rich DNA or RNA sequences in the human genome. G4 structures are liable for various biological functions; transcription, translation, cell aging as well as diseases such as cancer. These structures are therefore considered as important targets for the development of anticancer agents. Small organic heteroc...
Previous evidence indicates that telomeres resemble common fragile sites and present a challenge for DNA replication. The precise impediments to replication fork progression at telomeric TTAGGG repeats are unknown, but are proposed to include G-quadruplexes (G4) on the G-rich strand. Here we examined DNA synthesis and progression by the replicative DNA polymerase d/proliferating cell nuclear an...
High-resolution solution NMR spectroscopy has been used to characterize the structure of Pd dendrimer-encapsulated nanoparticles (DENs), consisting of approximately 55-atom nanoparticles encapsulated within fourth-generation, hydroxyl-terminated poly(amidoamine) PAMAM dendrimers (G4-OH). Detailed analysis of 1D and 2D NMR spectra of dendrimers with (G4-OH(Pd(55))) and without (G4-OH) nanopartic...
V(H)12 B cells undergo stringent selection at multiple checkpoints to favor development of B-1 cells that bind phosphatidylcholine. Selection begins with the V(H) third complementarity-determining region (CDR3) at the pre-B cell stage, in which most V(H)12 pre-B cells are selectively eliminated, enriching for those with V(H)CDR3s of 10 aa and a fourth position Gly (designated 10/G4). To underst...
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