Introduction: Laparoscopic cholecystectomy which is the gold standard of management gall bladder pathologies has variability in terms conversion to open procedure and operative difficulties according intraoperative findings.The G10 scoring system used predict diificulty outcome surgery. Aims And Objectives: The study aimed at assessment its anatomy surgical difficulty laparoscopic cholecystecto...

Encapsulation of guest molecules within the interior cavities of dendrimers is promising, but high generation dendrimers show limited encapsulation capacity due to their dense surface shell. Here, for the first time, we prove that high generation polyamidoamine dendrimers, such as generation 8 and generation 10, are able to encapsulate hydrophobic guests using NMR spectroscopy. Guest molecules ...

substrates Michal Borkovec Email. [email protected] July 31, 2012 Direct link www.colloid.ch/dendrimers Since their synthesis by Vögtle and Tomalia in the eighties, dendrimers have developed into an very interesting class of novel polymeric materials. Potential applications include surface patterning, synthesis of nanoparticles, or gene delivery. Our research group was much involved in t...

On June 3, 2003, the European Council of health ministers rejected a proposal from the European Commission to allow drug manufacturers to advertise directly to particular groups of patients; the proposal had already been rejected by the European Parliament subsequent to a heated public debate in which consumer and patient groups almost unanimously argued that it was not the role of drug compani...

We propose a direct and robust method for quantifying the variance risk premium on financial assets. We theoretically and numerically show that the risk-neutral expected value of the return variance, also known as the variance swap rate, is well approximated by the value of a particular portfolio of options. Ignoring the small approximation error, the difference between the realized variance an...

Book to market (BM) has long been associated with growth opportunities. We argue that after a negative shock to earnings, the BM of the firm is mainly determined by the shortterm recovery ability of the firm. Firms that have high (low) probability to recover from a negative shock will have low (high) BM after a negative shock. We confirm this relation both analytically and empirically and show ...

Assuming a product space model for biometric and financial events, there exists a rather natural principle for the decomposition of gains of life insurance contracts into a financial and a biometric part using orthogonal projections. In a discrete time framework, the paper shows the connection between this decomposition, locally variance-optimal hedging and the so-called pooling of biometric ri...

We propose a measure of systemic risk, ∆CoVaR, defined as the change in the value at risk of the financial system conditional on an institution being under distress relative to its median state. Our estimates show that characteristics such as leverage, size, maturity mismatch, and asset price booms significantly predict ∆CoVaR. We also provide out-of-sample forecasts of a countercyclical, forwa...