BACKGROUND The commercial test, SeptiFast, is designed to detect DNA from bacterial and fungal pathogens in whole blood. The method has been found to be specific with a high rule-in value for the early detection of septic patients. The software automatically provides information about the identified pathogen, without quantification of the pathogen. However, it is possible to manually derive Cro...

Characteristics of neonatal neutrophils Polymorphonuclear neutrophils (PMN) are key components of the innate immune system, provide first line immune defence mechanisms against pathogenic challenge, and are both quantitatively and qualitatively deficient in neonates. Neutrophil deficiencies contribute significantly to the increased susceptibility of neonates to serious and overwhelming bacteria...

The need for early antimicrobial therapy is well established for life-threatening bacterial and fungal infections including meningitis and sepsis/septic shock. However, a link between the outcome of serious viral infections and delays in antiviral therapy is not as well recognized. Recently, with the occurrence of the influenza A/H1N1 pandemic of 2009, a large body of data regarding this issue ...

31 Jackman S, Brereton RJ, Wright VM. Results of surgical treatment of neonatal necrotizing enterocolitis. BrJ Surg 1990, 77: 146-8. 32 Smith SD, Tagge EP, Miller J, Cheu H, Sukarochana K, Rowe MI. The hidden mortality in surgically treated necrotizing enterocolitis: fungal sepsis. J Pediatr Surg 1990; 25: 1030-3. 33 Cikrit D, Mastandrea J, West KW, Schreiner RL, Grosfeld JL. Necrotizing entero...

31 Jackman S, Brereton RJ, Wright VM. Results of surgical treatment of neonatal necrotizing enterocolitis. BrJ Surg 1990, 77: 146-8. 32 Smith SD, Tagge EP, Miller J, Cheu H, Sukarochana K, Rowe MI. The hidden mortality in surgically treated necrotizing enterocolitis: fungal sepsis. J Pediatr Surg 1990; 25: 1030-3. 33 Cikrit D, Mastandrea J, West KW, Schreiner RL, Grosfeld JL. Necrotizing entero...

In the past decade, mucormycosis has emerged as an important lethal infection in diabetics and other immunocompromised hosts. Rhinosinusitis, pansinusitis, rhino-orbital and rhinocerebral are the common classical manifestations of mucormycosis. However, primary gastrointestinal (GI) mucormycosis is an uncommon disease associated with a high mortality rate. Stomach is the most common site involv...

Glucose-6-phosphate dehydrogenase (G6PD) represents a common human enzyme defect, particularly prevalent in the Mediterranean, African e Asian area, where malaria was or is still endemic. Recently, we identified G6PD deficiency as a risk factor for developing invasive fungal disease (IFD) and particularly Candida Sepsis in patients undergoing intensive chemotherapy for acute myeloid leukemia (A...

INTRODUCTION Patients are at increased risk of cutaneous and systemic fungal infections when immunocompromised secondary to chemotherapy administration, hematopoietic and solid organ transplantation, diabetes, and AIDS. Those infections caused by Candida species are increasing in severity and frequency. Yarrowia lipolytica, formerly termed Candida lipolytica, has only recently been implicated a...

The potential of the systemic antifungal treatment of non-immunocompromised patients with sepsis, extra-digestive Candida colonization and multiple organ failure is unknown, although it represents three out of four antifungal treatments prescribed in intensive care units. It may allow an early treatment of invasive fungal infection at incubation phase, but exposes patients to unnecessary antifu...

mucormycosis is a rare opportunistic fungal infection that can implicate cranial sinuses, brain, lungs, gastrointestinal tract and skin. although it can occur in patients with competent and incompetent immunity such as patients with diabetes mellitus, lymphoma, leukemia and burns, but it has an aggressive, malignant and lethal course in patients with incompetent immunity. to enforce the importa...