Protection against the pathogenic fungus Histoplasma capsulatum requires Th1 cytokines. Since interleukin-4 (IL-4) can inhibit both Th1 cytokine production and activity, we examined the effects of overproduction of IL-4 in the lung on the course of pulmonary histoplasmosis. IL-4 lung transgenic mice manifested a higher fungal burden in their lungs, but not spleens, compared to wild-type infecte...

Eczema affecting hands and feet is one of the most common causes visit to a dermatologist. It can take chronic course leading significant agony patient also pose therapeutic challenge treating doctor. Clinical presentation, symptomatology disease activity varies from patient. One crucial step in management includes identification any underlying contact allergen avoiding it. At present, patch te...

few biomarkers that can predict the clinical response to allergen immunotherapy (ait) have been identified. the aim of the present study was to investigate parameters that could be used “in predicting the clinical response to ait” in children with asthma caused by house dust mites. we evaluated 107 children with mild persistent asthma who were sensitised only to mite aeroallergens. the study gr...

UNLABELLED The National Agricultural Biotechnology Information Center (NABIC) reconstructed an AllergenPro database for allergenic proteins analysis and allergenicity prediction. The AllergenPro is an integrated web-based system providing information about allergen in foods, microorganisms, animals and plants. The allergen database has the three main features namely, (1) allergen list with epit...

BACKGROUND Entomopathogenic fungi such as Beauveria bassiana are considered promising biological control agents for a variety of arthropod pests. Beauveria species, however, have the potential to elicit allergenic reactions in humans, although no specific allergens have been characterized to date. METHODS Four putative allergens were identified within B. bassiana expressed sequence tag (EST) ...

Tinea refers to superficial infection with one of three fungal genera-Microsporum, Epidermophyton, or Trichophyton-that are collectively known as dermatophytes. These infections are among the most common diseases worldwide and cause chronic morbidity. They are usually diagnosed by direct microscopy and fungal culture, which are burdensome to perform in the clinical setting. To supplement conven...

BACKGROUND The adaptive immunity underlying allergy comprises two components, the allergen-specific antibody (i.e. IgE, IgG) and the T-cell response. These two components are responsible for different disease manifestations and can be targeted by different therapeutic approaches. Here, we investigated the association of allergen-specific antibody and T- as well as B-cell responses in pollen-all...

Type 2 inflammation is found in most forms of asthma, which may co-exist with recurrent viral infections, bacterial colonization, and host cell death. These processes drive the accumulation intracellular cyclic-di-nucleotides such as cyclic-di-GMP (CDG). Group innate lymphoid cells (ILC2s) are critical drivers type lung during fungal allergen exposure mice; however, it unclear how CDG regulates...

BACKGROUND Malassezia commensal yeasts along with multitude of antigens have been found to be associated with various skin disorders including Pityriasis versicolor (PV). Amongst them Mala s1, a 37 kDa protein has been proved to be a major allergen reacting with a large panel of sera. However, there exists no therapeutic alternative to combat such problems in form of plant based natural compoun...

Results Of 1860 patients screened, 1097 (58.9 %) gave history of food allergy. Of the history positive patients 470 were skin prick tested . 29.3 % (138/470) exhibited positive reactions to one or more food(s). Rice elicited SPT positive reaction in maximum ( 6.2 %) cases followed by blackgram (5.9 %), lentil (5.5 %), citrus fruits (5.3 %), pea (3.8 %), maize (3.8%) and banana (3.6 %). Among fo...