In this issue of Blood, Noris et al describe a functional complement assay that can be used to diagnose atypical hemolytic-uremic syndrome (aHUS). This assay might also be useful in identifying aHUS patients in remission and in detecting asymptomatic carriers of complement gene mutations. Besides being used for diagnostic purposes, this assay potentially can be used to monitor anticomplement th...

Diagnostic assays for measurement of functional mannose-binding lectin (MBL) in serum are widely performed as part of immune status assessment. Classical pathway mediated complement activity can interfere in these functional MBL assays. Here we describe classical pathway interference incidentally occurring in a previously described hemolytic MBL assay and the modification of this assay to preve...

The γ-aminobutyric acid A (GABA(A)) ion channels are important drug targets for treatment of neurological and psychiatric disorders. Finding GABA(A) channel subtype selective allosteric modulators could lead to new improved treatments. However, the progress in this area has been obstructed by the challenging task of developing functional assays to support screening efforts and the generation of...

it is well known that a microperiodic function mapping a topological group into reals, which is continuous at some point is constant. we introduce the notion of a microperiodic multifunction, defined on a topological group with values in a metric space, and study regularity conditions implying an analogous result. we deal with vietoris and hausdorff continuity concepts.stability of microperiodi...

Objective(s): The aim of this study was to prepare fraction and determine the biological activities of the polyphenol-enriched fraction of Berberis integerrima Bunge fruits. Materials and Methods: In this assay fraction was extracted by column chromatography, using Amberlite column as the stationary phase. Phenol and flavonoids in the extract and fraction were analyzed by high performance liqui...

In the current study, ultrasonic assisted ethanolic extract of propolis was discussed in detail, including their total phenolic content, antioxidant capacity and radical scavenging capacity. For this purpose, we determined by CUPRAC FRAP) assay. At same time, free extracts investigated via DPPH• CUPRAC- hydroxyl (HRS) methods. The chemical constituents were characterized ATR-FTIR. results revea...

In the present study, a nanocrystalline Ni-Fe matrix with reinforced TiO2 nanoparticles as functional nanocomposite material was fabricated by pulsed current electroforming in UV-LIGA (lithography, electroplating, and molding). The influences of on deposition were also investigated using scanning electron microscopy, transmission vitro cytotoxicity assay. It found that 5 wt.% showed smooth surf...

won{gil park [won{gil park, j. math. anal. appl., 376 (1) (2011) 193{202] proved the hyers{ulam stability of the cauchy functional equation, the jensen functional equation and the quadraticfunctional equation in 2{banach spaces. one can easily see that all results of this paper are incorrect.hence the control functions in all theorems of this paper are not correct. in this paper, we correctthes...