Biologic function and the mechanical performance of vascular grafting materials are important predictors of graft patency. As such, "functional" materials that improve biologic integration and function have become increasingly sought after. An important alternative to synthetic materials is the use of biomaterials derived from ex vivo tissues that retain significant biologic and mechanical func...

Inflammatory bowel disease (IBD) coexists in up to 80% of patients with primary sclerosing cholangitis (PSC). PSC-IBD tends be mild and responsive mesalamine most patients. However, some may require immunosuppressive (IMM) or biologic therapy treat PSC-IBD. The aims this study are investigate the rates, predictors, outcomes biologic/IMM treatment This was a single center, retrospective PSC from...

Biologic therapies are becoming the preferred treatment option for many complex medical conditions, especially in the areas of oncology and immunology. Cytokines, monoclonal antibodies, and immunomodulators all have their own specific roles, clinical applications, mechanisms of action, and side effects. As newer biologic agents are approved and used for treatment, the nurse involved in the care...

SUMMARY Isohydroxyurea causes a rapid devitalization of E. coli C600. The effect of this agent on bacterial metabolism is manifested mainly in an inhibition in the synthesis of RNA. This is in marked contrast to the biologic action of the isomeric com pound, hydroxyurea, which is primarily bacteriostatic in na ture and which involves a specific block in DNA production. The lethal action of isoh...

“...I is this passion for beautiful colors that makes us paint as we do... and not the love of the ‘dot,’ as foolish people say,” wrote painter Paul Signac in his journal (1). He was defending the art movement started by his good friend and fellow artist George Seurat and built upon by Signac himself, Camille Pissarro, and others. This movement, divisionism or pointillism, was Seurat’s artistic...

Biologic therapies refer to genetically engineered treatments such as monoclonal antibodies and receptor-immunoglobulin fusion proteins. Following many disappointments, the introduction of anti-tumor necrosis factor (anti-TNF alpha) therapies into the clinic has clearly demonstrated the exciting potential of biologic agents. Many of these have been designed to modulate a specific aspect of the ...

GVA Gastroenterologists need to know that biologic agents have been under study for more than 15 years now, and a lot has been learned about their benefits and risks. The anti–tumor necrosis factor (TNF) agents are currently dominating the field of biologic therapy in inflammatory bowel disease (IBD). The armamentarium is relatively small for gastroenterologists compared with that for rheumatol...

OBJECTIVES To analyse the treatment sequencing assumptions after failure on a first-line biologic in cost-effectiveness models of treatment of moderate to severe plaque psoriasis, and to compare them with the most recent treatment guidelines. METHODS A systematic search of MEDLINE, Embase, EconLit and the Cochrane Library databases used free text and Medical Subject Headings terms including p...