Definitive treatment to achieve wound healing in major burns frequently include skin transplantation, where split-thickness grafts is considered gold standard. This method associated with several drawbacks. To overcome these hurdles, efforts have been made develop tissue engineered substitutes, often comprised of a combination cells and biomaterials. In the present study, we aimed investigate t...

Burn injuries remain a significant cause of morbidity and mortality during modern military conflicts and peacekeeping operations. Considering that commercially available dressings are not designed to meet the challenges of treating combat burn wounds, DRDC Toronto has designed a novel, absorbent and medicated bi-layer wound dressing to address key requirements for treating external war wounds. ...

The stimulatory effect of recombinant basic fibroblast growth factor (bFGF) on wound healing was assessed using healing-impaired (db/db) mice. Full-thickness wounds were made in female diabetic C57BL/KsJ db/db mice, and their normal (db/+) littermates with a punch biopsy instrument. Recombinant bFGF was applied locally to the open wound once a day. The mice were later killed and histological se...

Objective— Use of equine autologous keratinocyte on collagen membrane grafts (KCMG) for treatment of wounds in the distal aspect of the horse limb. Design— Experimental study Animals— Four horses. Procedure—Keratinocytes have been separated by enzyme digestion from lib skin sample and proliferated in vitro. Full thickness excision wounds (6.25 cm2) were created on the mid-lateral of both met...

The treatment of full thickness skin wounds commonly associated with large burns continues to represent a challenging clinical entity. The current treatment for large TBSA burns is split thickness autologous skin grafting; however, this treatment often results in poor textural durability, hypertrophic scarring, and fibrotic contractures. In this case report, we describe our experience and long-...