Antidepressant drugs modify in different ways the activity of neurons, by increasing monoamines levels and by modulating ion channels. Sodium channels are molecular targets for antiepileptic drugs, which can also be mood stabilizers (i.e. lamotrigine, topiramate, phenytoin, carbamazepine, valproic acid). After a short overview on the sodium channels and the interaction with antidepressants and ...

In the present study, we systematically investigated population differentiation of drug-related (DR) genes in order to identify common genetic features underlying population-specific responses to drugs. To do so, we used the International HapMap project release 27 Data and Pharmacogenomics Knowledge Base (PharmGKB) database. First, we compared four measures for assessing population differentiat...

OBJECTIVE Worldwide, many workers experience occupational exposure to organic solvents, which may induce chronic solvent-induced encephalopathy (CSE). Disturbances within the frontostriatothalamic (FST) circuitry might explain the symptomatology of CSE. We tested the hypothesis of FST circuitry abnormalities in CSE, as well as associations with performance of psychomotor speed, attention, and s...

Hunt and Sands (POPL’06) studied a flow sensitive type (FST) system for multi-level security, parametric in the choice of lattice of security levels. Choosing the powerset of program variables as the security lattice yields a system which was shown to be equivalent to Amtoft and Banerjee’s Hoare-style independence logic (SAS’04). Moreover, using the powerset lattice, it was shown how to derive ...

There is evidence to support a relationship between stress, depression, and alcoholism. Animal models have been developed to ascertain the impact of stress on depressive-like symptoms and ethanol intake. The swim test susceptible (SUS) line of rats selectively bred for enhanced susceptibility to stress-induced immobility in the forced swim test (FST) also show high voluntarily ethanol intake co...

Background: The basis for ethnic differences in cardiovascular disease (CVD) susceptibility is not fully understood. We investigated patterns of population differentiation (FST) of a set of genes in etiologic pathways of CVD among 3 ethnic groups: Yoruba in Nigeria (YRI), Utah residents with European ancestry (CEU), and Han Chinese (CHB) + Japanese (JPT). We identified 37 pathways implicated in...

The instability of an incompressible boundary-layer flow over infinite swept wing in the presence disc-type roughness elements and free-stream turbulence (FST) has been investigated by means direct numerical simulations. Our study corresponds to experiments Örlü et al. ( Tech. Rep. , KTH Royal Institute Technology, 2021, http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-291874 ). Here, different...

Serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitors represent important targets for the development of new treatments for detrusor overactivity and urinary incontinence. The present study was undertaken to investigate the effects of the forced swimming test (FST) on the contractile response of isolated rat detrusor muscle and to examine the effects of in vivo treatments of fluoxetine and ...

BACKGROUND Forward Surgical Teams (FST) provide forward deployed surgical care within the battle space. The next level of care in theater, the Combat Support Hospitals (CSH), are distinguished from the FST by advanced resource capabilities including more complex diagnostic imaging, laboratory support with blood banking, and intensive care units. This study was intended to assess the effect of F...