Enterotoxigenic Escherichia coli (ETEC) is the most common cause of diarrhea in children in developing countries and among travelers to ETEC endemic areas. ETEC diarrhea is caused by colonization of the small intestine mediated by colonization factor (CF) antigens, and subsequent elaboration of enterotoxins. Breast feeding has been related to protection against enteric infections. The protectiv...

BACKGROUND Infectious diseases cause many molecular assemblies and pathways within cellular signaling networks to function aberrantly. The most effective way to treat complex, diseased cellular networks is to apply multiple drugs that attack the problem from many fronts. However, determining the optimal combination of several drugs at specific dosages to reach an endpoint objective is a dauntin...

Stem cell-based disease modeling presents unique opportunities for mechanistic elucidation and therapeutic targeting. The stable induction of fate-specific differentiation is an essential prerequisite for stem cell-based strategy. Bone morphogenetic protein 2 (BMP-2) initiates receptor-regulated Smad phosphorylation, leading to the osteogenic differentiation of mesenchymal stromal/stem cells (M...

In the epithelial follicle stem cells (FSCs) of the Drosophila ovary, Epidermal Growth Factor Receptor (EGFR) signaling promotes self-renewal, whereas Notch signaling promotes differentiation of the prefollicle cell (pFC) daughters. We have identified two proteins, Six4 and Groucho (Gro), that link the activity of these two pathways to regulate the earliest cell fate decision in the FSC lineage...

Abstract. Friction stir consolidation (FSC) is a solid-state recycling method that directly converts machining scraps into semifinished billets. This process has been proven to be more energy efficient and environmentally friendly technique compared remelting based conventional methods. During FSC, chips are transformed solid billet by the stirring action friction heat of rotating tool. Due mec...

We have shown previously that liquid extraction surface analysis of dried blood spots coupled to high resolution top-down MS may be applied for the diagnosis of hemoglobin (Hb) variants FS, FAS, FC, FAC, FAD in newborn samples. The objective of the current work was to determine whether the structural variant HbE, compound heterozygote variants FSC and FSD, and β-thalassemia were amenable to dia...

Data mining has become an essential component in various fields of human life including business, education, medical and scientific. Cluster analysis is an important data mining technique used to find data segmentation and pattern recognition. This paper proposes the application of Fuzzy Subtractive Clustering (FSC) technique as an approach to define Big Five Patterns (B5P) using psychometric t...

'Touch' or trace biological samples submitted to caseworking labs as evidence often contain biological material from multiple individuals which can result in mixed DNA profiles. These mixture profiles are difficult to interpret and may cause analytical bottlenecks for forensic laboratories. The data in this brief reports the variation in the relative abundance of intact epithelial cells deposit...

The paper – similarly to our earlier publications since 1993 – is trying to ‘synchronize’ early quantum physics, the Kalmanian representation theory, Jungian analytic psychology, and certain aesthetical categories. The number ‘137’, the so-called inverse Fine Structure Constant (FSC), is placed at the centre of this heuristic and epistemological experiment, along with the scientific cooperation...