The structure of an allergen plays a crucial role in type I allergy. It is involved in the sensitization process as well as in allergic reactions that are caused by repetitive exposure. Here, we focused on the abundant group I allergens of grass pollen, which are known for their IgE inducing potential. We identified at least four independent IgE-binding regions (conformational epitopes) on the ...

Allergen component analysis is now available in many laboratories. The aim of this study was to examine the possible association between peanut allergen IgE components and severity of clinical reactions in patients with a history of peanut allergy. Data and sera collected from 192 patients within the Manchester Allergy Research Database and Serum Bank were used in this retrospective study. Sens...

BACKGROUND The prevalence of adverse food reactions (AFR) has been increasing in the western world. Clinical manifestations are diversified and it may not be possible to clinically discriminate between IgE and non-IgE mediated AFR. In Portugal, the prevalence of AFR and food allergies in children is not known. Thus, the objectives of this study were to determine the prevalence of AFR in central...

BACKGROUND : Eggplant (Solanum melongena L.) is known to cause food allergy in some Asian countries but detailed studies on eggplant allergy are lacking. OBJECTIVE : The objective is to investigate sensitization to different parts of eggplant fruit, and detection of the allergens. METHODS : Six eggplant-allergic subjects were assessed for sensitization to eggplant (peel/pulp, and raw/cooked...

BACKGROUND Oral allergy syndrome (OAS) is a unique allergic reaction to food, which is caused by cross-reactivity between proteins in fresh fruits or vegetables and pollens. Predisposing factors for OAS are not well known in patients with seasonal allergic rhinitis. OBJECTIVE Identify the probable risk factors for OAS in patients with seasonal allergic rhinitis. STUDY DESIGN One hundred and...

BACKGROUND Indigenous communities in Namibia possess a rich indigenous knowledge expressed within many practices of these communities. Indigenous wild edible fruits are available along the Namibian 13 regions of which it forms a rich source of vitamins, fibres, minerals and a heterogeneous collection of bioactive compounds referred to as phytochemicals for indigenous people's diet. The aim of t...

While the efficacy of classical subcutaneous allergen-specific immunotherapy (ASIT) has been proven by a multitude of double-blind placebo-controlled trials for various allergens and clinical conditions such as allergic rhinoconjuncitivis, allergic bronchial asthma or insect venom anaphylaxis, patients suffering from food allergy are still left with the simple recommendation of avoidance. This ...

Oral allergy syndrome (OAS) is one of the most common types of food allergy. The syndrome includes itching and swelling of the lips, palate and tongue, usually after consuming fresh fruits and vegetables. The underlying pathogenic mechanism is cross-reactivity between IgE antibodies specific to pollen, and antigens in food, such as fresh fruits, vegetables and nuts that are structurally similar...

Since the turn of the century, CM (cow's milk) formulas have become progressively more common as breast milk substitutes when mother's milk is unavailable, and CM allergy (CMA) has thus gradually become a more common disorder. Therefore the management of CMA infants confronts pediatricians and allergists with one of the most demanding challenges. In the first year of life of many children, CM p...

72 The Choice of Hypoallergens for Fish and Peach to Develop Food Allergy Specific Immunotherapy (TheFAST Project) Laurian Zuidmeer-Jongejan, PhD, Serge Versteeg, Lars Poulsen, MD, PhD, Montserrat Fernandez-Rivas, MD, PhD, Marek L. Kowalski, MD, PhD, Nikos Papadopoulos, Adriano Mari, MD, Ines Swoboda, PhD, Michael Clausen, MD, PhD, Carsten Bindslev-Jensen, MD, PhD, Angela Neubauer, PhD, Stef Ko...