The transcription factors mediating the development of CD1d-restricted invariant NKT (iNKT) cells remain incompletely described. Here, we show that loss of the AP-1 transcription factor Fra-2 causes a marked increase in the number of both thymic and peripheral iNKT cells, without affecting the development of other T-lineage cells. The defect is cell-autonomous and is evident in the earliest iNK...

Extensive studies have established that light regulates c-fos gene expression in the suprachiasmatic nucleus, the site of an endogenous circadian clock, but relatively little is known about the expression of genes structurally related to c-fos, including fra-1, fra-2 and fosB. We analysed the photic and temporal regulation of these genes at the messenger RNA and immunoreactive protein levels in...

BACKGROUND The mining industry is known worldwide for its highly risky and hazardous working environment. Technological advancement in ore extraction techniques for proliferation of production levels has caused further concern for safety in this industry. Research so far in the area of safety has revealed that the majority of incidents in hazardous industry take place because of human error, th...

The effect of experimental hematomas on serum levels of fibrinogen-related antigen (FRA) was studied in rabbits. Homologous blood used for production of hematomas was mixed with 131I-fibrinogen, and the measurement of FRA was made using a radioactive technique (representing FRA from hematoma) and immunologically (representing total FRA). Total body radiation of animals bearing hematomas contain...

The activator protein-1 (AP-1) transcription factor complex, in particular the Fos proteins, is an important regulator of bone homeostasis. Fra-2 (Fosl2), a Fos-related protein of the AP-1 family, is expressed in bone cells, and newborn mice lacking Fra-2 exhibit defects in chondrocytes and osteoclasts. Here we show that Fra-2-deficient osteoblasts display a differentiation defect both in vivo ...

PURPOSE Understanding the mechanisms that regulate gene expression in the human cornea is an important goal. In the present study, the involucrin gene was used as a model to study this regulation. Human involucrin (hINV) is a structural protein that is selectively expressed in surface epithelia, including corneal epithelial cells. METHODS Regulation of involucrin gene expression was monitored...

We developed, tested and validated a new Fast, Robust Automated (FRA) tool to detect solar-like oscillations. FRA is based on the detection measurement of frequency maximum oscillation power $\nu_{max}$, without relying regular spacing guide search. applied pipeline 254 synthetic spectra representative TESS red giants, as well 1689 giants observed by Kepler 2344 TESS. obtain consistency rate fo...

A frequency domain dynamic analysis is needed to obtain the response of structures constructed on a system of base isolators on flexible soil when subjected to earthquake ground motion. In such systems, the lateral stiffness of the base isolators is so small, compared to the structural stiffness, that in an earthquake attack the fundamental vibration mode dominates the response. With this in mi...

A frequency domain dynamic analysis is needed to obtain the response of structures constructed on a system of base isolators on flexible soil when subjected to earthquake ground motion. In such systems, the lateral stiffness of the base isolators is so small, compared to the structural stiffness, that in an earthquake attack the fundamental vibration mode dominates the response. With this in mi...