ZIERLER, KENNETH 1;. Hyperpolarisation of muscle by insulin in a glucose-free environment. Am. J. Physiol. ‘97(3) : 524-526. 1959. -In a glucose-free solution, insulin increased resting membrane potential of rat extensor digitorum longus muscle by as much as it had in the presence of glucose. Even in the absence of glucose there was probably net accumulation of potassium by muscle, but the incr...

During high-intensity submaximal exercise, muscle fatigue and decreased efficiency are intertwined closely, and each contributes to exercise intolerance. Fatigue and muscle inefficiency share common mechanisms, for example, decreased "metabolic stability," muscle metabolite accumulation, decreased free energy of adenosine triphosphate breakdown, limited O2 or substrate availability, increased g...

While the energy landscape theory of protein folding is now a widely accepted view for understanding how relatively weak molecular interactions lead to rapid and cooperative protein folding, such a framework must be extended to describe the large-scale functional motions observed in molecular machines. In this review, we discuss (1) the development of the energy landscape theory of biomolecular...

In this paper we derive the general equilibrium equations of a polymer chain with a noncircular cross section by the variation of the free energy functional. From the equilibrium equation of the elastic ribbon we derive analytically the equilibrium conformations both of the helical ribbons and the twisted ribbons. We find that the pitch angle of the helical ribbons depends on the ratio of the t...

BACKGROUND Current teaching suggests increased perfusion in free transverse rectus abdominis myocutaneous (TRAM) flaps over pedicled TRAM flaps, broadening indications for its use in high risk patients. This study compared perfusion analysis of free muscle-sparing versus pedicle TRAM flaps in vivo in the peri-operative and late post-operative periods. METHODS The SPY-Elite system using indocy...

Age-related changes in phospholipid and free cholesterol contents of hindleg muscles from normal and dystrophic (C57BL/6J dy/dy) mice were investigated. Free cholesterol contents in liver, whole blood and brain of dystrophic mice at 3 weeks of age were also compared with the control. Free cholesterol content tended to increase in the liver of the dystrophic mouse. Free cholesterol content of dy...

This study explores the impact of the extensive use of an oral device since infancy (pacifier) on the acquisition of concrete, abstract, and emotional concepts. While recent evidence showed a negative relation between pacifier use and children's emotional competence (Niedenthal et al., 2012), the possible interaction between use of pacifier and processing of emotional and abstract language has ...

According to Mednick's (1962) theory of individual differences in creativity, creative individuals appear to have a richer and more flexible associative network than less creative individuals. Thus, creative individuals are characterized by "flat" (broader associations) instead of "steep" (few, common associations) associational hierarchies. To study these differences, we implement a novel comp...

INTRODUCTION As the population ages, the number of injured elderly is increasing. We sought to determine if low skeletal muscle mass adversely affected outcome in elderly patients following trauma. METHODS Patients ≥ 65 years of age with an admission abdominal computed tomography scan and requiring intensive care unit (ICU) stay at a Level I trauma center in 2009-2010 were reviewed. Muscle cr...