Cicatrização anormal pode levar à transformação maligna. Carcinoma de células escamosas de uma ferida crônica não cicatrizada é chamada de úlcera de Marjolin, e este processo é geralmente associado com queimaduras. Úlcera de Marjolin, em oposição ao câncer da pele espontâneo, é mais provável que ocorra nas extremidades, e tem padrão altamente agressivo, com 27,5% de pacientes desenvolvendo metá...

OBJECTIVE To describe and analyze the clinical and dermoscopic characteristics of desmoplastic melanoma (DM) as a function of pathologic subtype and phenotypic traits. DESIGN Retrospective case series. SETTING Eight high-risk dermatology clinics. PATIENTS Patients with DM confirmed by histopathologic analysis whose records included a high-quality dermoscopic image. MAIN OUTCOME MEASURES...

The diagnosis of pigmented actinic keratosis (PAK) is often challenging because of overlapping features with lentigo maligna. OBJECTIVE To investigate dermoscopic patterns of PAK according to their different evolutionary stages, and to correlate the pattern with clinical characteristics of the patients. METHODS Descriptive and analytical study of 232 PAK. Dermoscopic patterns were divided i...

BACKGROUND Melanomas with poorly defined borders, lack of pigmentation, lentiginous extension, and location in cosmetically sensitive regions represent diagnostic and therapeutic challenges. Repeated surgical reexcisions are frequently required to achieve tumor-free margins. The use of reflectance mode confocal microscopy as an noninvasive method has shown to be a promising tool for diagnosing ...

Four types of facial pigmented skin lesions (FPSLs) constitute diagnostic challenge to dermatologists; early seborrheic keratosis (SK), pigmented actinic keratosis (AK), lentigo maligna (LM), and solar lentigo (SL). A retrospective analysis of dermoscopic images of histopathologically diagnosed clinically-challenging 64 flat FPSLs was conducted to establish the dermoscopic findings correspondin...

Lentigo maligna has an extensive and neoplastic character. It typically progresses slowly and may eventually develop into an invasive melanoma, which is called lentigo maligna melanoma. Ocular melanoma is the second most common type of melanoma. The uvea is the most common site of origin of ocular melanomas, while conjunctival melanoma accounts for about 1-5% of cases. In this article, we descr...

Skin cancer has been shown to present asymmetrically, prevalent on the left side of the body, more so in subtypes of cutaneous melanoma such as lentigo maligna. Biases have been linked to cumulative UV light exposure and automobile driving patterns. Though left-right ratios have previously correlated with the side men or women tend to position themselves or countries drive on, more recent trend...

R adiation therapy (RT) has been an established modality for treating various types of cancers since the early 1900s. It became more broadly utilized in cancer therapy beginning in the 1960s, with greater accessibility to radioactive sources such as cobalt-60 and the emergence of the linear accelerator. The linear accelerator is a piece of equipment that instead of requiring a radioactive sourc...

Because of many recent diagnostic and therapeutic advances, malignant mel-anoma has been receiving new notoriety. Nevertheless, it is far from a new disease. Hippocrates (1) is credited with the first description of the lesion, which has always been regarded with some fear and superstition. There was little contribution of any significance until the seventeenth century, when Highmore, Bartholin...

2014 Skin cancer was not a potent selective force in the evolution of protective pigmentation in early hominins. Greaves [1] proposed that skin cancer was a potent selective force for the evolution of dark pigmentation in early hominins. Blum [2,3] questioned the role of skin cancer in the evolution of skin pigmentation because it only rarely causes death to individuals of reproductive age. Sin...