Evidence is lacking on whether the duration and timing of low socioeconomic position (SEP) across a person’s life course may be associated with incidence of type 2 diabetes mellitus (T2D). The authors’ objectives were to investigate associations between cumulative SEP and the incidence of T2D in the Framingham Offspring Study (n 1⁄4 1,893; 52% women; mean baseline age 1⁄4 34 years). Pooled logi...

TYPE 2 DIABETES MELLITUS AND ITS precursor, impaired glucose tolerance (IGT), are associated with increased risk for morbidity and mortality from cardiovascular disease (CVD), particularly coronary heart disease. An increased prevalence of traditional risk factors for atherosclerosis (eg, hypertension, low high-density lipoprotein cholesterol [HDL-C] levels) occurs in type 2 diabetes and IGT, b...

The prognostic value of abnormalities on the electrocardiogram (ECG) present 1 year after initial myocardial infarction (MI) is examined in relation to reinfarction and coronary death throughout 32 years (mean, 10.1 years) of follow-up in the Framingham Heart Study. Resting 12-lead ECGs were available in 251 survivors (190 men and 61 women) of clinically recognized Q wave MI. The ECG reverted t...

Background. Lipoprotein(a) [Lp(a)J is an atherogenic particle that structurally resembles a low density lipoprotein (LDL) particle but contains a molecule of apolipoprotein(a) attached to apolipoprotein B-100 by a disulfide bond. Because elevated plasma levels of Lp(a) have been shown to be an independent risk factor for coronary artery disease, it is important to define normal ranges for this ...

BACKGROUND Several risk factors for cardiovascular disease (CVD) have been identified in recent decades. However, the association between the health system and the burden of CVD has not yet been sufficiently researched. The objective of this study was to analyse the association between health system development and the burden of CVD, in particular CVD-related disability-adjusted life-years (DAL...

OBJECTIVES To evaluate whether the association between migraine with aura and increased risk of cardiovascular disease is modified by vascular risk groups as measured by the Framingham risk score for coronary heart disease. DESIGN Prospective cohort study. SETTING Women's health study, United States. PARTICIPANTS 27 519 women who were free from cardiovascular disease at baseline with avai...

OBJECTIVES Several studies found a significant association between earlobe crease (ELC) and cardiovascular disease (CVD). Metabolic syndrome (MS) is a group of high-risk factors that are a collection of cardiovascular risk factors. Scant data are available about the relationship between ELC and MS. The purpose of the current study was to examine the correlation between ELC and MS. METHODS A c...

National Heart, Lung, and Blood Institute’s Framingham Heart Study (CSL, MGL, EJB, RSV), Framingham, MA; Department of Biostatistics (XL, QY, MJP) and Epidemiology (EJB), Boston University School of Public Health, Boston, MA; Department of Mathematics and Statistics, Boston University, Boston, MA (MGL); Harvard Medical School, Boston, Mass (JA); Mayo Clinic, Rochester, MN (MMR, CSL), Cardiology...

1 Genetics Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 2 National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, MA 3 Division of Endocrinology, Brigham and Women's Hospital and Harvard Medical School, Boston, Department of Pathology, Beth Israel Deaconess Hospital, Harvard Medical School Harvard Stem C...

Conall M. O’Seaghdha* and Caroline S. Fox*** *National Heart, Lung, and Blood Institute’s Framingham Offspring Study and the Center for Population Studies, Framingham, Massachusetts; Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland; Renal Division and Division of Endocrinology, Brigham and Women’s Hospital, Boston, Massachusetts; Renal Division, Mas...