The common fragile site, FRA3B, has been shown to be a site of frequent homozygous deletions in some cancers, resulting in loss of expression of the associated FHIT gene. It has been proposed that FHIT is a tumor suppressor gene that is inactivated as a result of the instability of FRA3B in tumorigenesis. More recently, deletions at other common fragile sites, FRA7G and FRA16D, have been identi...

The fragile X chromosome, associated with a common form of X-linked mental retardation, is cytologically observed most often as a gap or fragile site near the distal end of the long arm in band Xq28. Expression of this site is variable and dependent upon lowered thymidylate pools. In order to examine the behavior of this fragile site in a foreign genetic background, interspecific somatic cell h...

The health care system in Papua New Guinea is fragile, and surveillance systems infrequently meet international standards. To strengthen outbreak identification, health authorities piloted a mobile phone-based syndromic surveillance system and used established frameworks to evaluate whether the system was meeting objectives. Stakeholder experience was investigated by using standardized question...

This paper aims towards better understanding the role of entrepreneurship in fragile states, which despite the practical interest and relevance has been somewhat disregarded in academic research. Given the necessity to support policy formulation with appropriate and relevant measurement of entrepreneurship and the business environment, the primary focus in this paper is to scrutinize existing i...

Cyanophyta of some paddy-fields of Golestan province (North of Iran, near the Caspian Sea) have been studied during 2006–07. Phormidium subinerusatum, P. tenue, P. jadinianum, P. purpurascens, P. lucidum, P. fragile, Microcoleus palaodus, M. lacustris are new records for Golestan province and Iran. Results showed that  P. subinerusatum, P. tenue were dominant in all stations. P. fragile, in spr...

The response of an F-actin network at the air-buffer interface to nonlinear compression is studied. We observe two distinct classes of behavior: a mechanically induced structural reorganization of the monolayer and a subsequent reversible, nonlinear mechanical response. Measurements of pressure area isotherms, bulk modulus, and the epifluorescence microscopy of tracer beads provide evidence tha...

We previously reported the isolation of a gene (FMR-1) expressed in brain at the fragile X locus. One exon of this gene lies within an EcoRI fragment that exhibits length variation in fragile X patients. This exon also contains the CGG repeat within the CpG island hypermethylated in fragile X patients. To study the involvement of the FMR-1 gene in the fragile X syndrome, its expression was stud...

We analyse the Coulomb cohesion of wet granular materials and its relationship with the distribution of capillary bonds between particles. We show that, within a harmonic representation of the bond and force states, the shear strength can be expressed as a state equation in terms of internal anisotropy parameters. This formulation involves a dependence of the shear strength on loading direction...