نتایج جستجو برای: foxo1

تعداد نتایج: 2363  

2016
Valentina Guzmán-Pérez Christiane Bumke-Vogt Monika Schreiner Inga Mewis Andrea Borchert Andreas F. H. Pfeiffer

Nasturtium (Tropaeolum majus L.) contains high concentrations of benzylglcosinolate. We found that a hydrolysis product of benzyl glucosinolate-the benzyl isothiocyanate (BITC)-modulates the intracellular localization of the transcription factor Forkhead box O 1 (FOXO1). FoxO transcription factors can antagonize insulin effects and trigger a variety of cellular processes involved in tumor suppr...

Journal: :The Journal of clinical investigation 2005
Michael Potente Carmen Urbich Ken-ichiro Sasaki Wolf K Hofmann Christopher Heeschen Alexandra Aicher Ramya Kollipara Ronald A DePinho Andreas M Zeiher Stefanie Dimmeler

Forkhead box O (Foxo) transcription factors are emerging as critical transcriptional integrators among pathways regulating differentiation, proliferation, and survival, yet the role of the distinct Foxo family members in angiogenic activity of endothelial cells and postnatal vessel formation has not been studied. Here, we show that Foxo1 and Foxo3a are the most abundant Foxo isoforms in mature ...

Journal: :American journal of physiology. Endocrinology and metabolism 2010
Kristy Iskandar Yongheng Cao Yoshitake Hayashi Masanori Nakata Eisuke Takano Toshihiko Yada Changliang Zhang Wataru Ogawa Miyo Oki Streamson Chua Hiroshi Itoh Tetsuo Noda Masato Kasuga Jun Nakae

Both insulin and leptin signaling converge on phosphatidylinositol 3-OH kinase [PI(3)K]/3-phosphoinositide-dependent protein kinase-1 (PDK-1)/protein kinase B (PKB, also known as Akt) in proopiomelanocortin (POMC) neurons. Forkhead box-containing protein-O1 (FoxO1) is inactivated in a PI(3)K-dependent manner. However, the interrelationship between PI(3)K/PDK-1/Akt and FoxO1, and the chronic eff...

Journal: :American journal of physiology. Cell physiology 2007
David L Allen Terry G Unterman

Myostatin, a member of the transforming growth factor (TGF)-beta family, plays an important role in regulating skeletal muscle growth and differentiation. Here we examined the role of FoxO1 and SMAD transcription factors in regulating myostatin gene expression and myoblast differentiation in C(2)C(12) myotubes in vitro. Both myostatin and FoxO1 mRNA expression were greater in fast- vs. slow-twi...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2011
Satoru Kyo Junko Sakaguchi Tohru Kiyono Yutaka Shimizu Yoshiko Maida Yasunari Mizumoto Noriko Mori Mitsuhiro Nakamura Masahiro Takakura Kiyohiko Miyake Masaru Sakamoto Masaki Inoue

PURPOSE AND EXPERIMENTAL DESIGN Despite the therapeutic utility of progestin in invasive and preinvasive endometrial neoplasias, the molecular mechanisms through which it exerts inhibitory effects on endometrial epithelial growth are largely unknown. The aim of the study was to clarify the molecular mechanisms of progestin action to endometrial epithelial cells using originally established in v...

2015
Michel Schmitt-Ney Giovanni Camussi

PAX3-FOXO1 (PAX3-FKHR) is the fusion protein produced by the genomic translocation that characterizes the alveolar subtype of Rhabdomyosarcoma, a pediatric sarcoma with myogenic phenotype. PAX3-FOXO1 is an aberrant but functional transcription factor. It retains PAX3-DNA-binding activity and functionally overlaps PAX3 function while also disturbing it, in particular its role in myogenic differe...

2009
Jun Tanaka Li Qiang Alexander S. Banks Carrie L. Welch Michihiro Matsumoto Tadahiro Kitamura Yukari Ido-Kitamura Ronald A. DePinho Domenico Accili

OBJECTIVE Atherosclerotic cardiovascular disease is the leading cause of death among people with diabetes. Generation of oxidized LDLs and reduced nitric oxide (NO) availability because of endothelial NO synthase (eNOS) dysfunction are critical events in atherosclerotic plaque formation. Biochemical mechanism leading from hyperglycemia to oxLDL formation and eNOS dysfunction is unknown. RESEA...

2009
Yann M Kerdiles Daniel R Beisner Roberto Tinoco Anne S Dejean Diego H Castrillon Ronald A DePinho Stephen M Hedrick

Foxo transcription factors have a conserved role in the adaptation of cells and organisms to nutrient and growth factor availability. Here we show that Foxo1 has a crucial, nonredundant role in T cells. In naive T cells, Foxo1 controlled the expression of the adhesion molecule L-selectin, the chemokine receptor CCR7 and the transcription factor Klf2, and its deletion was sufficient to alter lym...

Journal: :The Journal of clinical investigation 2012
Aruna Kode Ioanna Mosialou Barbara C Silva Marie-Therese Rached Bin Zhou Ji Wang Tim M Townes Rene Hen Ronald A DePinho X Edward Guo Stavroula Kousteni

Serotonin is a critical regulator of bone mass, fulfilling different functions depending on its site of synthesis. Brain-derived serotonin promotes osteoblast proliferation, whereas duodenal-derived serotonin suppresses it. To understand the molecular mechanisms of duodenal-derived serotonin action on osteoblasts, we explored its transcriptional mediation in mice. We found that the transcriptio...

Journal: :The Journal of clinical investigation 2006
Michihiro Matsumoto Seongah Han Tadahiro Kitamura Domenico Accili

Hepatic insulin resistance affects both carbohydrate and lipid metabolism. It has been proposed that insulin controls these 2 metabolic branches through distinct signaling pathways. FoxO transcription factors are considered effectors of the pathway regulating hepatic glucose production. Here we show that adenoviral delivery of constitutively nuclear forkhead box O1 (FoxO1) to mouse liver result...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید